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IL20RA interleukin 20 receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 53832, updated on 2-Aug-2021

Summary

Official Symbol
IL20RAprovided by HGNC
Official Full Name
interleukin 20 receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:6003
See related
Ensembl:ENSG00000016402 MIM:605620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha
Summary
This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in skin (RPKM 13.8), adrenal (RPKM 3.9) and 13 other tissues See more
Orthologs
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Genomic context

See IL20RA in Genome Data Viewer
Location:
6q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (136999971..137044965, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137321108..137366317, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 3 Neighboring gene neuroblastoma highly expressed 1 Neighboring gene interleukin 22 receptor subunit alpha 2 Neighboring gene interferon gamma receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-20 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-20 receptor subunit alpha
Names
class II cytokine receptor ZCYTOR7
cytokine receptor family 2 member 8
interleukin 20 receptor alpha subunit
interleukin 20 receptor, alpha
interleukin-20 receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278722.2NP_001265651.2  interleukin-20 receptor subunit alpha isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-most exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL135902
    Consensus CDS
    CCDS64536.1
    Related
    ENSP00000437843.1, ENST00000541547.5
    Conserved Domains (2) summary
    pfam01108
    Location:174
    Tissue_fac; Tissue factor
    pfam09294
    Location:86190
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  2. NM_001278723.3NP_001265652.2  interleukin-20 receptor subunit alpha isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL135902
    Consensus CDS
    CCDS64535.1
    Related
    ENSP00000356722.1, ENST00000367748.4
    Conserved Domains (1) summary
    pfam09294
    Location:25128
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  3. NM_001278724.4NP_001265653.2  interleukin-20 receptor subunit alpha isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL135902
    Conserved Domains (1) summary
    pfam09294
    Location:21106
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  4. NM_014432.4NP_055247.4  interleukin-20 receptor subunit alpha isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL135902
    Consensus CDS
    CCDS5181.1
    Related
    ENSP00000314976.5, ENST00000316649.10
    Conserved Domains (2) summary
    pfam01108
    Location:27123
    Tissue_fac; Tissue factor
    pfam09294
    Location:135239
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    136999971..137044965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010954.2XP_016866443.1  interleukin-20 receptor subunit alpha isoform X1

  2. XM_011535904.2XP_011534206.1  interleukin-20 receptor subunit alpha isoform X3

    UniProtKB/Swiss-Prot
    Q9UHF4
    Conserved Domains (1) summary
    pfam09294
    Location:25128
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  3. XM_017010955.1XP_016866444.1  interleukin-20 receptor subunit alpha isoform X2

  4. XM_006715506.2XP_006715569.1  interleukin-20 receptor subunit alpha isoform X4

    Conserved Domains (1) summary
    pfam09294
    Location:21106
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
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