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P2RY13 purinergic receptor P2Y13 [ Homo sapiens (human) ]

Gene ID: 53829, updated on 21-Dec-2019

Summary

Official Symbol
P2RY13provided by HGNC
Official Full Name
purinergic receptor P2Y13provided by HGNC
Primary source
HGNC:HGNC:4537
See related
Ensembl:ENSG00000181631 MIM:606380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR1; GPR86; GPR94; P2Y13; SP174; FKSG77
Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]
Expression
Broad expression in spleen (RPKM 21.1), appendix (RPKM 14.3) and 18 other tissues See more
Orthologs

Genomic context

See P2RY13 in Genome Data Viewer
Location:
3q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151326312..151329549, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151044096..151047337, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene purinergic receptor P2Y14 Neighboring gene SET pseudogene 11 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y12 Neighboring gene immunoglobulin superfamily member 10 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
biological_process ND
No biological Data available
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
negative regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P2Y purinoceptor 13
Names
G protein-coupled receptor 86
G-protein coupled receptor 94
purinergic receptor P2Y, G-protein coupled, 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176894.3NP_795713.2  P2Y purinoceptor 13

    See identical proteins and their annotated locations for NP_795713.2

    Status: REVIEWED

    Source sequence(s)
    AC024886, DA676457
    Consensus CDS
    CCDS3158.2
    UniProtKB/Swiss-Prot
    Q9BPV8
    Related
    ENSP00000320376.5, ENST00000325602.6
    Conserved Domains (1) summary
    pfam00001
    Location:62317
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151326312..151329549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713664.1XP_006713727.1  P2Y purinoceptor 13 isoform X1

    Conserved Domains (1) summary
    PHA03087
    Location:50164
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023914.2: Suppressed sequence

    Description
    NM_023914.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to include intronic sequence.
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