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FXYD7 FXYD domain containing ion transport regulator 7 [ Homo sapiens (human) ]

Gene ID: 53822, updated on 3-May-2025
Official Symbol
FXYD7provided by HGNC
Official Full Name
FXYD domain containing ion transport regulator 7provided by HGNC
Primary source
HGNC:HGNC:4034
See related
Ensembl:ENSG00000221946 MIM:606684; AllianceGenome:HGNC:4034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]
Expression
Biased expression in brain (RPKM 25.1) and spleen (RPKM 0.7) See more
Orthologs
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See FXYD7 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35143255..35154302)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37687602..37698927)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35634159..35645205)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat LGI family member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35632134-35632696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35633820-35634380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35634381-35634942 Neighboring gene FXYD domain containing ion transport regulator 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:35642007-35642406 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:35643105-35643656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35644606-35645470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14457 Neighboring gene FXYD domain containing ion transport regulator 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:35666754-35666910 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:35693985-35694502 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35694503-35695020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35695021-35695538 Neighboring gene uncharacterized LOC105372379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35702580-35703391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14460

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Clone Names

  • FLJ25096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
 
enables ion channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
FXYD domain-containing ion transport regulator 7

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022006.2NP_071289.1  FXYD domain-containing ion transport regulator 7

    See identical proteins and their annotated locations for NP_071289.1

    Status: REVIEWED

    Source sequence(s)
    AC020907
    Consensus CDS
    CCDS12446.1
    UniProtKB/Swiss-Prot
    P58549
    Related
    ENSP00000270310.2, ENST00000270310.7
    Conserved Domains (1) summary
    cd20325
    Location:1262
    FXYD7; FXYD domain-containing ion transport regulator 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35143255..35154302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37687602..37698927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321225.1XP_054177200.1  FXYD domain-containing ion transport regulator 7 isoform X1

    UniProtKB/Swiss-Prot
    P58549