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CELSR2 cadherin EGF LAG seven-pass G-type receptor 2 [ Bos taurus (domestic cattle) ]

Gene ID: 538194, updated on 30-Jan-2025
Official Symbol
CELSR2provided by VGNC
Official Full Name
cadherin EGF LAG seven-pass G-type receptor 2provided by VGNC
Primary source
VGNC:VGNC:27170
See related
BGD:BT17107; EnsemblRapid:ENSBTAG00070014503
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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See CELSR2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (34131467..34157510, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene myosin binding protein H like Neighboring gene proline and serine rich coiled-coil 1 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene uncharacterized LOC132344864 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1

Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cadherin EGF LAG seven-pass G-type receptor 2
Names
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192931.1 → NP_001179860.1  cadherin EGF LAG seven-pass G-type receptor 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000003
    UniProtKB/TrEMBL
    E1BJ11, G3MXZ5
    Related
    ENSBTAP00070019236.1, ENSBTAT00070032796.1
    Conserved Domains (9) summary
    smart00303
    Location:2312 → 2365
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:401 → 498
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:1969 → 2031
    HormR; Domain present in hormone receptors
    smart00180
    Location:1921 → 1966
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1286 → 1321
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1366 → 1549
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:1829 → 1862
    EGF; EGF-like domain
    pfam16489
    Location:2049 → 2284
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:2371 → 2602
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34131467..34157510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024989583.2 → XP_024845351.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X2

    UniProtKB/TrEMBL
    G3MXZ5
    Related
    ENSBTAP00070019246.1, ENSBTAT00070032821.1
    Conserved Domains (10) summary
    smart00303
    Location:2312 → 2365
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:401 → 498
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:1969 → 2031
    HormR; Domain present in hormone receptors
    smart00180
    Location:1921 → 1966
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1286 → 1321
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1366 → 1549
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:1829 → 1862
    EGF; EGF-like domain
    pfam16489
    Location:2048 → 2286
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15992
    Location:2373 → 2397
    7tmB2_CELSR2; TM helix 1 [structural motif]
    cl28897
    Location:2370 → 2623
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_024989582.2 → XP_024845350.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X1

    UniProtKB/TrEMBL
    G3MXZ5
    Conserved Domains (10) summary
    smart00303
    Location:2312 → 2365
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:401 → 498
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:1969 → 2031
    HormR; Domain present in hormone receptors
    smart00180
    Location:1921 → 1966
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1286 → 1321
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1366 → 1549
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:1829 → 1862
    EGF; EGF-like domain
    pfam16489
    Location:2048 → 2286
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15992
    Location:2373 → 2397
    7tmB2_CELSR2; TM helix 1 [structural motif]
    cl28897
    Location:2370 → 2623
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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