MAPK7 mitogen-activated protein kinase 7 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: MAPK7provided by VGNC
Official Full Name: mitogen-activated protein kinase 7provided by VGNC
Primary source: VGNC:VGNC:31222
See related: BGD:BT22411; EnsemblRapid:ENSBTAG00000001014
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: ERK-5
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ARS-UCD1.2 (GCF_002263795.1)	19	NC_037346.1 (34085200..34091163, complement)
105	previous assembly	Bos_taurus_UMD_3.1.1 (GCF_000003055.6)	19	AC_000176.1 (34687986..34693256, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_21800-21801:1025034309:1 (e-PCR)
- UniSTS:268632

STS-U29725 (e-PCR)
- UniSTS:72402

Mapk7 (e-PCR), detects polymorphism
- UniSTS:516574

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to laminar fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitogen-activated protein kinase 7

Names: BMK1 kinase; Big MAP kinase 1; Extracellular signal-regulated kinase 5; MAP kinase 7; MAPK 7

NP_001092550.1

EC 2.7.11.24

XP_005220440.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099080.2 → NP_001092550.1 mitogen-activated protein kinase 7

See identical proteins and their annotated locations for NP_001092550.1

Status: PROVISIONAL

Source sequence(s)

BC142510

UniProtKB/Swiss-Prot

A5PKJ4

Related

ENSBTAP00000001347.6, ENSBTAT00000001347.7

Conserved Domains (2) summary

smart00220
Location:55 → 347

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD1.2 Primary Assembly

Range

34085200..34091163 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005220383.4 → XP_005220440.1 mitogen-activated protein kinase 7 isoform X1

See identical proteins and their annotated locations for XP_005220440.1

UniProtKB/Swiss-Prot

A5PKJ4

Conserved Domains (2) summary

smart00220
Location:55 → 347

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5