U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAPK7 mitogen-activated protein kinase 7 [ Bos taurus (cattle) ]

Gene ID: 537703, updated on 7-Sep-2023

Summary

Official Symbol
MAPK7provided by VGNC
Official Full Name
mitogen-activated protein kinase 7provided by VGNC
Primary source
VGNC:VGNC:31222
See related
BGD:BT22411; EnsemblRapid:ENSBTAG00000001014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ERK-5
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MAPK7 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 19 NC_037346.1 (34085200..34091163, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 19 AC_000176.1 (34687986..34693256, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 112 Neighboring gene microfibril associated protein 4 Neighboring gene ethylene-responsive transcription factor ABI4-like Neighboring gene uncharacterized LOC101902854 Neighboring gene B9 domain containing 1

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC148520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to laminar fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of response to cytokine stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 7
Names
BMK1 kinase
Big MAP kinase 1
Extracellular signal-regulated kinase 5
MAP kinase 7
MAPK 7
NP_001092550.1
XP_005220440.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099080.2NP_001092550.1  mitogen-activated protein kinase 7

    See identical proteins and their annotated locations for NP_001092550.1

    Status: PROVISIONAL

    Source sequence(s)
    BC142510
    UniProtKB/Swiss-Prot
    A5PKJ4
    Related
    ENSBTAP00000001347.6, ENSBTAT00000001347.7
    Conserved Domains (2) summary
    smart00220
    Location:55347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    34085200..34091163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005220383.4XP_005220440.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_005220440.1

    UniProtKB/Swiss-Prot
    A5PKJ4
    Conserved Domains (2) summary
    smart00220
    Location:55347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5