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DDAH1 dimethylarginine dimethylaminohydrolase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 537391, updated on 10-Feb-2026
Official Symbol
DDAH1provided by VGNC
Official Full Name
dimethylarginine dimethylaminohydrolase 1provided by VGNC
Primary source
VGNC:VGNC:27939
See related
EnsemblRapid:ENSBTAG00070008217
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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Try the new Transcripts and proteins table
See DDAH1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (58618306..58775117)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101904769 Neighboring gene cellular communication network factor 1 Neighboring gene DDB1- and CUL4-associated factor 16-like Neighboring gene chromosome 3 C1orf52 homolog Neighboring gene BCL10 immune signaling adaptor

Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Frey D, et al. Structure, 2006 May. PMID 16698551
  2. Characterization of dimethylargininase from bovine brain: evidence for a zinc binding site. Bogumil R, et al. Biochemistry, 1998 Apr 7. PMID 9537995
  3. Isolation and characterization of a novel monomeric zinc- and heme-containing protein from bovine brain. Fundel SM, et al. FEBS Lett, 1996 Oct 14. PMID 8849684
  4. Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production. Pope AJ, et al. J Biol Chem, 2009 Dec 18. PMID 19820234, Free PMC Article
  5. Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation. Pope AJ, et al. Am J Physiol Cell Physiol, 2007 Nov. PMID 17881609

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDAH-1 and DDAH-2 manifest their effects through different mechanisms, the former of which is largely ADMA-dependent and the latter ADMA-independent.
    Title: Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production.
  2. High-resolution crystal structures of DDAH isoform 1 was presented.
    Title: Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors.
  3. dimethylargininase-1 inhibited upon specific Cys-S-nitrosylation.
    Title: Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation.
  4. Demonstrate a critical role for DDAH-1 and endogenous methylarginines in the pathogenesis of endothelial dysfunction.
    Title: Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC165853

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dimethylargininase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in citrulline metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Names
DDAH-1
DDAHI
dimethylargininase-1
NP_001095671.1
XP_024845341.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102201.2 → NP_001095671.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

    See identical proteins and their annotated locations for NP_001095671.1

    Status: PROVISIONAL

    Source sequence(s)
    BC149998
    UniProtKB/Swiss-Prot
    A6QQU7, P56965, P81020
    Conserved Domains (1) summary
    cl19186
    Location:42 → 276
    Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    58618306..58775117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024989573.2 → XP_024845341.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X1

    Related
    ENSBTAP00070010874.1, ENSBTAT00070018548.1
    Conserved Domains (1) summary
    cl19186
    Location:9 → 179
    Amidinotransf; Amidinotransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56965.3 GenPept UniProtKB/Swiss-Prot:P56965

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Research Materials
Miscellaneous