PNOC prepronociceptin [Homo sapiens (human)] - Gene

Summary

Official Symbol: PNOCprovided by HGNC
Official Full Name: prepronociceptinprovided by HGNC
Primary source: HGNC:HGNC:9163
See related: Ensembl:ENSG00000168081 MIM:601459; AllianceGenome:HGNC:9163
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ
Summary: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
Expression: Biased expression in brain (RPKM 7.7), lymph node (RPKM 5.0) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p21.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (28316988..28343351)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (28595062..28621518)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (28174785..28200868)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology.
Title: PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology.
found differences in Neonatal Abstinence Syndrome outcomes depending on PNOC and COMT SNP genotype.
Title: Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity.
The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants.
Title: Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant.
Study presents evidence suggesting that the PNOC and OPRL1 are dysregulated in suicide completers, thereby potentially contributing to impaired emotional and behavioral control and, ultimately, to the suicidal crisis
Title: Decreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides.
findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS severity.
Title: Variations in opioid receptor genes in neonatal abstinence syndrome.
Data suggest that nociceptin/nociceptin receptor signaling in neurons of the hippocampus modulate learning and memory. [REVIEW]
Title: Nociceptin/orphanin-FQ modulation of learning and memory.
Data suggest that interaction between the nociceptin/nociceptin receptor system and the orexin/orexin receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
Title: The neuronal circuit between nociceptin/orphanin FQ and hypocretins/orexins coordinately modulates stress-induced analgesia and anxiety-related behavior.
Data suggest that the nociceptin/nociceptin receptor system is involved in modulation of psychological and inflammatory stress responses and in pathogenesis of anxiety. [REVIEW]
Title: Endogenous nociceptin system involvement in stress responses and anxiety behavior.
Data suggest that the nociceptin/nociceptin receptor system is involved in modulation of the immune response and in pathogenesis of autoimmune diseases. [REVIEW]
Title: Nociceptin/orphanin FQ-NOP receptor system in inflammatory and immune-mediated diseases.
Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW]
Title: Effects of nociceptin and nocistatin on uterine contraction.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-18480 (e-PCR)
- UniSTS:31008

STS-U48263 (e-PCR)
- UniSTS:11307

WI-15701 (e-PCR)
- UniSTS:61998

D8S1809 (e-PCR), detects polymorphism
- UniSTS:19898

SHGC-110036 (e-PCR)
- UniSTS:170174

PNOC (e-PCR)
- UniSTS:479993

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables opioid peptide activity	IEA Inferred from Electronic Annotation more info
enables opioid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in neuron-neuron synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prepronociceptin

Names: nociceptin; nocistatin; orphanin FQ; pre-pro-N/OFQ; pronociceptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284244.2 → NP_001271173.1 prepronociceptin isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) lacks a signal peptide sequence and has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC021678, BF976583, CA412176

Consensus CDS

CCDS64862.1

UniProtKB/Swiss-Prot

Q13519

Related

ENSP00000430145.1, ENST00000522209.1
NM_006228.5 → NP_006219.1 prepronociceptin isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC021678, BC034758

Consensus CDS

CCDS6066.1

UniProtKB/Swiss-Prot

B7Z749, Q13519, Q6FH16

UniProtKB/TrEMBL

A8K0R8

Related

ENSP00000301908.3, ENST00000301908.8

Conserved Domains (1) summary

pfam01160
Location:22 → 66

Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

28316988..28343351

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544559.3 → XP_011542861.1 prepronociceptin isoform X1

UniProtKB/TrEMBL

A8K0R8

Conserved Domains (1) summary

pfam01160
Location:22 → 65

Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
XM_005273532.3 → XP_005273589.1 prepronociceptin isoform X1

UniProtKB/TrEMBL

A8K0R8

Conserved Domains (1) summary

pfam01160
Location:22 → 65

Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

28595062..28621518

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054360696.1 → XP_054216671.1 prepronociceptin isoform X1

UniProtKB/TrEMBL

A8K0R8
XM_054360695.1 → XP_054216670.1 prepronociceptin isoform X1

UniProtKB/TrEMBL

A8K0R8