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PNOC prepronociceptin [ Homo sapiens (human) ]

Gene ID: 5368, updated on 8-Jul-2021

Summary

Official Symbol
PNOCprovided by HGNC
Official Full Name
prepronociceptinprovided by HGNC
Primary source
HGNC:HGNC:9163
See related
Ensembl:ENSG00000168081 MIM:601459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
Expression
Biased expression in brain (RPKM 7.7), lymph node (RPKM 5.0) and 8 other tissues See more
Orthologs
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Genomic context

See PNOC in Genome Data Viewer
Location:
8p21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (28316979..28343355)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28174785..28200868)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 7 (enigma) pseudogene Neighboring gene ribosomal protein L5 pseudogene 22 Neighboring gene zinc finger protein 395 Neighboring gene RNA, U6 small nuclear 178, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables opioid peptide activity IEA
Inferred from Electronic Annotation
more info
 
enables opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory perception IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
prepronociceptin
Names
nociceptin
nocistatin
orphanin FQ
pre-pro-N/OFQ
pronociceptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284244.2NP_001271173.1  prepronociceptin isoform 2

    See identical proteins and their annotated locations for NP_001271173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) lacks a signal peptide sequence and has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC021678, BF976583, CA412176
    Consensus CDS
    CCDS64862.1
    UniProtKB/Swiss-Prot
    Q13519
    Related
    ENSP00000430145.1, ENST00000522209.1
  2. NM_006228.5NP_006219.1  prepronociceptin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006219.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC021678, BC034758
    Consensus CDS
    CCDS6066.1
    UniProtKB/Swiss-Prot
    Q13519
    Related
    ENSP00000301908.3, ENST00000301908.8
    Conserved Domains (1) summary
    pfam01160
    Location:2266
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    28316979..28343355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544559.2XP_011542861.1  prepronociceptin isoform X1

    See identical proteins and their annotated locations for XP_011542861.1

    Conserved Domains (1) summary
    pfam01160
    Location:2265
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  2. XM_005273532.2XP_005273589.1  prepronociceptin isoform X1

    See identical proteins and their annotated locations for XP_005273589.1

    Conserved Domains (1) summary
    pfam01160
    Location:2265
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
  3. XM_017013578.1XP_016869067.1  prepronociceptin isoform X2

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