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PTOV1 PTOV1 extended AT-hook containing adaptor protein [ Homo sapiens (human) ]

Gene ID: 53635, updated on 24-Nov-2020

Summary

Official Symbol
PTOV1provided by HGNC
Official Full Name
PTOV1 extended AT-hook containing adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:9632
See related
Ensembl:ENSG00000104960 MIM:610195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACID2; PTOV-1
Summary
This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in testis (RPKM 29.1), adrenal (RPKM 28.7) and 25 other tissues See more
Orthologs

Genomic context

See PTOV1 in Genome Data Viewer
Location:
19q13.33
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49848554..49860744)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50353667..50363999)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372435 Neighboring gene fuzzy planar cell polarity protein Neighboring gene mediator complex subunit 25 Neighboring gene microRNA 6800 Neighboring gene PTOV1 antisense RNA 1 Neighboring gene PTOV1 antisense RNA 2 Neighboring gene microRNA 4749 Neighboring gene polynucleotide kinase 3'-phosphatase Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71475, DKFZp586I111

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
prostate tumor-overexpressed gene 1 protein
Names
activator interaction domain-containing protein 2
prostate tumor overexpressed 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050666.1 RefSeqGene

    Range
    6892..16901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001305105.2NP_001292034.1  prostate tumor-overexpressed gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_001292034.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.
    Source sequence(s)
    AA582677, AC018766, AJ617480
    Consensus CDS
    CCDS12782.1
    UniProtKB/Swiss-Prot
    Q86YD1
    Related
    ENSP00000469128.1, ENST00000599732.5
    Conserved Domains (1) summary
    pfam11232
    Location:93238
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  2. NM_001305108.1NP_001292037.1  prostate tumor-overexpressed gene 1 protein isoform 2

    See identical proteins and their annotated locations for NP_001292037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' region, initiates translation at an alternate start codon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AA582677, AK057817, AY358168
    Consensus CDS
    CCDS82379.1
    UniProtKB/Swiss-Prot
    Q86YD1
    UniProtKB/TrEMBL
    A0A0C4DGR2
    Related
    ENSP00000471458.1, ENST00000600603.5
    Conserved Domains (1) summary
    pfam11232
    Location:61206
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  3. NM_001364745.2NP_001351674.1  prostate tumor-overexpressed gene 1 protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018766
    Related
    ENSP00000469541.1, ENST00000601638.5
    Conserved Domains (1) summary
    pfam11232
    Location:61206
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  4. NM_001364747.2NP_001351676.1  prostate tumor-overexpressed gene 1 protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC018766
    Conserved Domains (2) summary
    pfam11232
    Location:108253
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    cl26247
    Location:1156
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  5. NM_001364748.2NP_001351677.1  prostate tumor-overexpressed gene 1 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC018766
    Conserved Domains (1) summary
    pfam11232
    Location:117258
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  6. NM_001364749.2NP_001351678.1  prostate tumor-overexpressed gene 1 protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC018766
    Conserved Domains (2) summary
    pfam11232
    Location:108253
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    cl26247
    Location:1156
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  7. NM_001364750.2NP_001351679.1  prostate tumor-overexpressed gene 1 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC018766
    Related
    ENST00000598325.5
    Conserved Domains (1) summary
    pfam11232
    Location:117258
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  8. NM_017432.5NP_059128.2  prostate tumor-overexpressed gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_059128.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This transcript contains splicing in the 3' UTR that makes it a candidate for nonsense-mediated mRNA decay (NMD). However, this protein is thought to be valid.
    Source sequence(s)
    AA582677, AC018766, BC042921
    Consensus CDS
    CCDS12782.1
    UniProtKB/Swiss-Prot
    Q86YD1
    Related
    ENSP00000472816.1, ENST00000601675.5
    Conserved Domains (1) summary
    pfam11232
    Location:93238
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2

RNA

  1. NR_130963.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in two exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA582677, AC018766, AK057817
    Related
    ENST00000601612.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49848554..49860744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527034.3XP_011525336.1  prostate tumor-overexpressed gene 1 protein isoform X6

    Conserved Domains (1) summary
    pfam11232
    Location:108253
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  2. XM_024451541.1XP_024307309.1  prostate tumor-overexpressed gene 1 protein isoform X1

    Conserved Domains (2) summary
    pfam11232
    Location:108253
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    cl26247
    Location:1156
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  3. XM_017026879.2XP_016882368.1  prostate tumor-overexpressed gene 1 protein isoform X3

    Conserved Domains (2) summary
    pfam11232
    Location:108253
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    cl26247
    Location:1156
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  4. XM_024451543.1XP_024307311.1  prostate tumor-overexpressed gene 1 protein isoform X4

    Conserved Domains (1) summary
    pfam11232
    Location:61206
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  5. XM_024451542.1XP_024307310.1  prostate tumor-overexpressed gene 1 protein isoform X2

    Conserved Domains (1) summary
    pfam11232
    Location:93238
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
  6. XM_024451544.1XP_024307312.1  prostate tumor-overexpressed gene 1 protein isoform X7

    Conserved Domains (1) summary
    pfam11232
    Location:117258
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
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