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Insm1 insulinoma-associated 1 [ Mus musculus (house mouse) ]

Gene ID: 53626, updated on 28-May-2024

Summary

Official Symbol
Insm1provided by MGI
Official Full Name
insulinoma-associated 1provided by MGI
Primary source
MGI:MGI:1859980
See related
Ensembl:ENSMUSG00000068154 AllianceGenome:MGI:1859980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IA-1
Summary
Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and cyclin binding activity. Involved in several processes, including glandular epithelial cell differentiation; nervous system development; and norepinephrine biosynthetic process. Acts upstream of or within positive regulation of cell migration; positive regulation of cell population proliferation; and type B pancreatic cell development. Located in nucleus. Is expressed in several structures, including adrenal gland; branchial arch; gut; nervous system; and sensory organ. Orthologous to human INSM1 (INSM transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Insm1 in Genome Data Viewer
Location:
2 G1; 2 71.33 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (146064021..146066940)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (146221997..146225020)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5996 Neighboring gene STARR-positive B cell enhancer mm9_chr2:145783203-145783504 Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene STARR-seq mESC enhancer starr_05934 Neighboring gene cilia and flagella associated protein 61 Neighboring gene STARR-seq mESC enhancer starr_05935 Neighboring gene STARR-seq mESC enhancer starr_05936 Neighboring gene predicted gene, 34629 Neighboring gene RIKEN cDNA A930019D19 gene Neighboring gene Ral GTPase activating protein, alpha subunit 2 (catalytic) Neighboring gene STARR-seq mESC enhancer starr_05939 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adrenal chromaffin cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocrine system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in noradrenergic neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pancreatic A cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pancreatic A cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type B pancreatic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulinoma-associated protein 1
Names
insulinoma-associated protein (IA-1)
zinc finger protein IA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016889.4NP_058585.2  insulinoma-associated protein 1

    See identical proteins and their annotated locations for NP_058585.2

    Status: VALIDATED

    Source sequence(s)
    AL935056
    Consensus CDS
    CCDS16830.1
    UniProtKB/Swiss-Prot
    Q63ZV0, Q9Z113
    UniProtKB/TrEMBL
    Q05BD7
    Related
    ENSMUSP00000092048.4, ENSMUST00000089257.6
    Conserved Domains (2) summary
    sd00017
    Location:274294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:373395
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    146064021..146066940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)