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Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) [ Mus musculus (house mouse) ]

Gene ID: 53623, updated on 8-Jan-2023

Summary

Official Symbol
Gria3provided by MGI
Official Full Name
glutamate receptor, ionotropic, AMPA3 (alpha 3)provided by MGI
Primary source
MGI:MGI:95810
See related
Ensembl:ENSMUSG00000001986 AllianceGenome:MGI:95810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluA3; Glur3; GluR-C; Glur-3; GluR-K3; Gluralpha3; 2900064I19Rik
Summary
This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in frontal lobe adult (RPKM 31.4), cortex adult (RPKM 28.9) and 7 other tissues See more
Orthologs
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Genomic context

See Gria3 in Genome Data Viewer
Location:
X A4; X 23.19 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (40489351..40767478)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (41400819..41678601)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene 14577 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4184

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables AMPA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in parallel fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor 3
Names
AMPA-selective glutamate receptor 3
glutamate receptor channel alpha3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281929.2NP_001268858.2  glutamate receptor 3 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AL672232, AL672290
    Consensus CDS
    CCDS30097.1
    UniProtKB/Swiss-Prot
    Q5DTJ0
    UniProtKB/TrEMBL
    A0A6P7QLB0, A0A8C6N1X7
    Conserved Domains (2) summary
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06387
    Location:29403
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
  2. NM_001290451.3NP_001277380.2  glutamate receptor 3 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and contains an alternate exon and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is the same length but has a different sequence than isoform a.
    Source sequence(s)
    AL672232, AL672290
    Consensus CDS
    CCDS72370.1
    UniProtKB/TrEMBL
    A0A6P5P753, A0A8C6HYY6, B0QZW1
    Related
    ENSMUSP00000131523.2, ENSMUST00000165288.2
    Conserved Domains (2) summary
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06387
    Location:29403
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
  3. NM_001358361.2NP_001345290.2  glutamate receptor 3 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AL672232, AL672290
    Consensus CDS
    CCDS30097.1
    UniProtKB/Swiss-Prot
    Q5DTJ0
    UniProtKB/TrEMBL
    A0A6P7QLB0, A0A8C6N1X7
    Conserved Domains (2) summary
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06387
    Location:29403
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
  4. NM_016886.5NP_058582.4  glutamate receptor 3 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AL672232, AL672290
    Consensus CDS
    CCDS30097.1
    UniProtKB/Swiss-Prot
    Q5DTJ0
    UniProtKB/TrEMBL
    A0A6P7QLB0, A0A8C6N1X7
    Related
    ENSMUSP00000075687.6, ENSMUST00000076349.12
    Conserved Domains (2) summary
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06387
    Location:29403
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor

RNA

  1. NR_104053.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL672232, AL672290
    Related
    ENSMUST00000139965.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    40489351..40767478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318545.3XP_017174034.1  glutamate receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5DTJ0, Q9Z2W9
    UniProtKB/TrEMBL
    A0A6P7QLB0, A0A8C6N1X7
    Conserved Domains (2) summary
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06387
    Location:29403
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
  2. XM_017318547.3XP_017174036.1  glutamate receptor 3 isoform X3

    Conserved Domains (2) summary
    cd06387
    Location:29403
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cl21456
    Location:416687
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. XM_017318546.1XP_017174035.1  glutamate receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A6P5P753, A0A8C6HYY6, B0QZW1
    Related
    ENSMUSP00000110755.3, ENSMUST00000115103.9
    Conserved Domains (2) summary
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06387
    Location:29403
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor