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Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) [ Mus musculus (house mouse) ]

Gene ID: 53623, updated on 12-Aug-2018

Summary

Official Symbol
Gria3provided by MGI
Official Full Name
glutamate receptor, ionotropic, AMPA3 (alpha 3)provided by MGI
Primary source
MGI:MGI:95810
See related
Ensembl:ENSMUSG00000001986 Vega:OTTMUSG00000017323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluA3; Glur3; GluR-C; Glur-3; GluR-K3; Gluralpha3; 2900064I19Rik
Summary
This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in frontal lobe adult (RPKM 31.4), cortex adult (RPKM 28.9) and 7 other tissues See more
Orthologs

Genomic context

See Gria3 in Genome Data Viewer
Location:
X A4; X 23.19 cM
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (41401118..41678601)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (38754481..39031778)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene 40S ribosomal protein S27-like pseudogene Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4184

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
synaptic cleft ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor 3
Names
AMPA-selective glutamate receptor 3
glutamate receptor channel alpha3 subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281929.1NP_001268858.1  glutamate receptor 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001268858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AK135043, AL672290, BC076584, BC086678, BY266507
    Consensus CDS
    CCDS30097.1
    UniProtKB/Swiss-Prot
    Q9Z2W9
    UniProtKB/TrEMBL
    Q0VGS8, Q3UY17
    Conserved Domains (2) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  2. NM_001290451.2NP_001277380.1  glutamate receptor 3 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and contains an alternate exon and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is the same length but has a different sequence than isoform a.
    Source sequence(s)
    AB022342, AL672232, AL672290, BC086678
    Consensus CDS
    CCDS72370.1
    UniProtKB/Swiss-Prot
    Q9Z2W9
    Related
    ENSMUSP00000131523.1, ENSMUST00000165288.1
    Conserved Domains (4) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40383
    ANF_receptor; Receptor family ligand binding region
  3. NM_001358361.1NP_001345290.1  glutamate receptor 3 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AB022342, AL672232, AL672290, BC086678
    Conserved Domains (2) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  4. NM_016886.4NP_058582.3  glutamate receptor 3 isoform a precursor

    See identical proteins and their annotated locations for NP_058582.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AK135043, BC076584, BC086678, BY266507
    Consensus CDS
    CCDS30097.1
    UniProtKB/Swiss-Prot
    Q9Z2W9
    UniProtKB/TrEMBL
    Q0VGS8, Q3UY17
    Related
    ENSMUSP00000075687.5, OTTMUSP00000041290, ENSMUST00000076349.11, OTTMUST00000077886
    Conserved Domains (2) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

RNA

  1. NR_104053.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC076584, BC086678, BY266507
    Related
    ENSMUST00000139965.7, OTTMUST00000077887

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    41401118..41678601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318546.1XP_017174035.1  glutamate receptor 3 isoform X2

    UniProtKB/TrEMBL
    B0QZW1
    Conserved Domains (2) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  2. XM_017318545.1XP_017174034.1  glutamate receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2W9
    Conserved Domains (2) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  3. XM_006541520.3XP_006541583.1  glutamate receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2W9
    Conserved Domains (2) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  4. XM_011251015.1XP_011249317.1  glutamate receptor 3 isoform X2

    UniProtKB/TrEMBL
    B0QZW1
    Conserved Domains (2) summary
    cd06387
    Location:29400
    PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
    cd13715
    Location:416799
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  5. XM_017318547.1XP_017174036.1  glutamate receptor 3 isoform X3

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