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Map3k6 mitogen-activated protein kinase kinase kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 53608, updated on 12-May-2024

Summary

Official Symbol
Map3k6provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 6provided by MGI
Primary source
MGI:MGI:1855691
See related
Ensembl:ENSMUSG00000028862 AllianceGenome:MGI:1855691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ask2; MEKK6; MAPKKK6
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Is expressed in vibrissa. Orthologous to human MAP3K6 (mitogen-activated protein kinase kinase kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 10.4), genital fat pad adult (RPKM 9.5) and 21 other tissues See more
Orthologs
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Genomic context

See Map3k6 in Genome Data Viewer
Location:
4 D2.3; 4 66.25 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132965290..132980240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133237979..133252929)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptor 3 Neighboring gene CD164 sialomucin-like 2 Neighboring gene ficolin C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2126 Neighboring gene synaptotagmin-like 1 Neighboring gene transmembrane protein 222 Neighboring gene STARR-seq mESC enhancer starr_11620

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC159280

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 6
Names
apoptosis signal-regulating kinase 2
NP_057902.5
XP_006539103.1
XP_006539104.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016693.5NP_057902.5  mitogen-activated protein kinase kinase kinase 6

    Status: VALIDATED

    Source sequence(s)
    AL671882, AL837525
    Consensus CDS
    CCDS18744.1
    UniProtKB/Swiss-Prot
    A2AE93, Q0VBN3, Q9WTR2
    UniProtKB/TrEMBL
    A0A0A0MQ82
    Related
    ENSMUSP00000030677.7, ENSMUST00000030677.7
    Conserved Domains (3) summary
    smart00220
    Location:654907
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:640907
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130507
    DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132965290..132980240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539040.4XP_006539103.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    A2AE93, Q0VBN3, Q9WTR2
    Conserved Domains (2) summary
    cd06624
    Location:632899
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130500
    DUF4071; Domain of unknown function (DUF4071)
  2. XM_006539041.4XP_006539104.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

    Conserved Domains (1) summary
    pfam13281
    Location:130508
    DUF4071; Domain of unknown function (DUF4071)