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BRAF B-Raf proto-oncogene, serine/threonine kinase [ Bos taurus (domestic cattle) ]

Gene ID: 536051, updated on 20-Feb-2025
Official Symbol
BRAFprovided by VGNC
Official Full Name
B-Raf proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:26551
See related
BGD:BT25565; EnsemblRapid:ENSBTAG00070032866
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See BRAF in Genome Data Viewer
Location:
chromosome: 4
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (104016173..104194462, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104972256 Neighboring gene uncharacterized LOC132345136 Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene uncharacterized LOC112446483 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene uncharacterized LOC101907501 Neighboring gene mitochondrial ribosomal protein S33

Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
serine/threonine-protein kinase B-raf
XP_005205968.1
XP_005205973.1
XP_005205974.1
XP_005205975.1
XP_024846954.1
XP_024846956.1
XP_024846957.1
XP_059741940.1
XP_059741941.1
XP_059741942.1
XP_059741943.1
XP_059741944.1
XP_059741945.1
XP_059741946.1
XP_059741947.1
XP_059741948.1
XP_059741949.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    104016173..104194462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059885960.1 → XP_059741943.1  serine/threonine-protein kinase B-raf isoform X4

    UniProtKB/TrEMBL
    A0AAA9T2F0

  2. XM_059885958.1 → XP_059741941.1  serine/threonine-protein kinase B-raf isoform X2

    UniProtKB/TrEMBL
    A0AAA9T2F0

  3. XM_059885957.1 → XP_059741940.1  serine/threonine-protein kinase B-raf isoform X1

    UniProtKB/TrEMBL
    A0AAA9T2F0

  4. XM_059885959.1 → XP_059741942.1  serine/threonine-protein kinase B-raf isoform X3

    UniProtKB/TrEMBL
    A0AAA9T2F0

  5. XM_059885961.1 → XP_059741944.1  serine/threonine-protein kinase B-raf isoform X5

    UniProtKB/TrEMBL
    F1MDL4

  6. XM_005205911.5 → XP_005205968.1  serine/threonine-protein kinase B-raf isoform X9

    See identical proteins and their annotated locations for XP_005205968.1

    UniProtKB/TrEMBL
    A0AAA9T2F0
    Related
    ENSBTAP00070045288.1, ENSBTAT00070074339.1
    Conserved Domains (4) summary
    cd01816
    Location:155 → 226
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:462 → 714
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00069
    Location:457 → 712
    Pkinase; Protein kinase domain
    pfam00130
    Location:234 → 279
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  7. XM_024991189.2 → XP_024846957.1  serine/threonine-protein kinase B-raf isoform X8

    UniProtKB/TrEMBL
    A0AAA9T2F0
    Related
    ENSBTAP00070045325.1, ENSBTAT00070074410.1
    Conserved Domains (3) summary
    cd01816
    Location:155 → 226
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:462 → 709
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:234 → 279
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  8. XM_024991188.2 → XP_024846956.1  serine/threonine-protein kinase B-raf isoform X7

    UniProtKB/TrEMBL
    A0AAA9T2F0, A0AAA9T3I8
    Related
    ENSBTAP00070045274.1, ENSBTAT00070074316.1
    Conserved Domains (3) summary
    cd01816
    Location:155 → 226
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:462 → 709
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:234 → 279
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  9. XM_059885966.1 → XP_059741949.1  serine/threonine-protein kinase B-raf isoform X16

    UniProtKB/TrEMBL
    A0AAA9SS15, A0AAA9T2F0
    Related
    ENSBTAP00070045256.1, ENSBTAT00070074284.1

  10. XM_024991186.2 → XP_024846954.1  serine/threonine-protein kinase B-raf isoform X6

    UniProtKB/TrEMBL
    A0AAA9T2F0
    Conserved Domains (3) summary
    cd01816
    Location:155 → 226
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:462 → 709
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:234 → 279
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  11. XM_059885965.1 → XP_059741948.1  serine/threonine-protein kinase B-raf isoform X13

    UniProtKB/TrEMBL
    A0A3Q1LML5
    Related
    ENSBTAP00070045345.1, ENSBTAT00070074450.1

  12. XM_059885963.1 → XP_059741946.1  serine/threonine-protein kinase B-raf isoform X11

    UniProtKB/TrEMBL
    A0AAA9T2F0

  13. XM_059885962.1 → XP_059741945.1  serine/threonine-protein kinase B-raf isoform X10

    UniProtKB/TrEMBL
    A0AAA9T2F0

  14. XM_059885964.1 → XP_059741947.1  serine/threonine-protein kinase B-raf isoform X12

    UniProtKB/TrEMBL
    A0AAA9T2F0

  15. XM_005205916.5 → XP_005205973.1  serine/threonine-protein kinase B-raf isoform X14

    See identical proteins and their annotated locations for XP_005205973.1

    UniProtKB/TrEMBL
    A0A3Q1M353
    Conserved Domains (4) summary
    cd01816
    Location:155 → 226
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:462 → 665
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:234 → 279
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam07714
    Location:456 → 662
    Pkinase_Tyr; Protein tyrosine kinase

  16. XM_005205918.3 → XP_005205975.1  serine/threonine-protein kinase B-raf isoform X15

    UniProtKB/TrEMBL
    A0A3Q1M353
    Conserved Domains (4) summary
    cd01816
    Location:155 → 226
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:462 → 663
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:234 → 279
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam07714
    Location:456 → 662
    Pkinase_Tyr; Protein tyrosine kinase

  17. XM_005205917.5 → XP_005205974.1  serine/threonine-protein kinase B-raf isoform X14

    See identical proteins and their annotated locations for XP_005205974.1

    UniProtKB/TrEMBL
    A0A3Q1M353
    Related
    ENSBTAP00070045228.1, ENSBTAT00070074236.1
    Conserved Domains (4) summary
    cd01816
    Location:155 → 226
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:462 → 665
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:234 → 279
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam07714
    Location:456 → 662
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein Strain
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