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Tslp thymic stromal lymphopoietin [ Mus musculus (house mouse) ]

Gene ID: 53603, updated on 8-Dec-2022

Summary

Official Symbol
Tslpprovided by MGI
Official Full Name
thymic stromal lymphopoietinprovided by MGI
Primary source
MGI:MGI:1855696
See related
Ensembl:ENSMUSG00000024379 AllianceGenome:MGI:1855696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cytokine activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in extracellular region. Is expressed in ductus deferens; epididymis; ileum; and testis. Used to study atopic dermatitis; autoimmune hemolytic anemia; cryoglobulinemia; and membranoproliferative glomerulonephritis. Orthologous to human TSLP (thymic stromal lymphopoietin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 2.0), limb E14.5 (RPKM 0.6) and 12 other tissues See more
Orthologs
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Genomic context

See Tslp in Genome Data Viewer
Location:
18 B1; 18 18.12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32948436..32952852)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32815383..32819799)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25826 Neighboring gene RIKEN cDNA 4930455D15 gene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene, 26378 Neighboring gene WD repeat domain 36

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-7 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to fungus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine (C-C motif) ligand 1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thymic stromal lymphopoietin
Names
thymic stroma-derived lymphopoietin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021367.2NP_067342.1  thymic stromal lymphopoietin precursor

    See identical proteins and their annotated locations for NP_067342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC140983, AK087266, CJ198416
    Consensus CDS
    CCDS29121.1
    UniProtKB/Swiss-Prot
    Q9JIE6
    Related
    ENSMUSP00000025237.4, ENSMUST00000025237.5
    Conserved Domains (1) summary
    pfam15216
    Location:20137
    TSLP; Thymic stromal lymphopoietin

RNA

  1. NR_033206.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three exons and contains a unique 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK087266, CJ198416
    Related
    ENSMUST00000234876.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    32948436..32952852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)