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Tslp thymic stromal lymphopoietin [ Mus musculus (house mouse) ]

Gene ID: 53603, updated on 28-Oct-2018

Summary

Official Symbol
Tslpprovided by MGI
Official Full Name
thymic stromal lymphopoietinprovided by MGI
Primary source
MGI:MGI:1855696
See related
Ensembl:ENSMUSG00000024379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in bladder adult (RPKM 2.0), limb E14.5 (RPKM 0.6) and 12 other tissues See more
Orthologs

Genomic context

See Tslp in Genome Data Viewer
Location:
18 B1; 18 18.12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (32815383..32819799)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (32975037..32979453)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene glycophorin C Neighboring gene predicted gene, 35480 Neighboring gene RIKEN cDNA 4930455D15 gene Neighboring gene WD repeat domain 36 Neighboring gene microRNA 6361

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-7 receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
defense response to fungus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of growth of symbiont on or near host surface ISO
Inferred from Sequence Orthology
more info
 
positive regulation of STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine (C-C motif) ligand 1 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of granulocyte colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-5 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thymic stromal lymphopoietin
Names
thymic stroma-derived lymphopoietin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021367.2NP_067342.1  thymic stromal lymphopoietin precursor

    See identical proteins and their annotated locations for NP_067342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC140983, AK087266, CJ198416
    Consensus CDS
    CCDS29121.1
    UniProtKB/Swiss-Prot
    Q9JIE6
    Related
    ENSMUSP00000025237.3, ENSMUST00000025237.3
    Conserved Domains (1) summary
    pfam15216
    Location:20137
    TSLP; Thymic stromal lymphopoietin

RNA

  1. NR_033206.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three exons and contains a unique 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK087266, CJ198416

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    32815383..32819799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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