U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pcdh12 protocadherin 12 [ Mus musculus (house mouse) ]

Gene ID: 53601, updated on 9-May-2024

Summary

Official Symbol
Pcdh12provided by MGI
Official Full Name
protocadherin 12provided by MGI
Primary source
MGI:MGI:1855700
See related
Ensembl:ENSMUSG00000024440 AllianceGenome:MGI:1855700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcdh14; VE-cad-2
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; glycogen metabolic process; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in cell-cell junction. Is expressed in several structures, including central nervous system; extraembryonic component; heart; placenta; and retina. Orthologous to human PCDH12 (protocadherin 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 6.4), placenta adult (RPKM 4.4) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pcdh12 in Genome Data Viewer
Location:
18 B3; 18 20.17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38400145..38417454, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38267092..38284401, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700086O06 gene Neighboring gene 60S ribosomal protein L17-like Neighboring gene STARR-positive B cell enhancer ABC_E7580 Neighboring gene STARR-seq mESC enhancer starr_44353 Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene ring finger protein 14 Neighboring gene STARR-seq mESC enhancer starr_44354 Neighboring gene predicted gene, 23205 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10986 Neighboring gene predicted gene, 41702

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
protocadherin-12
Names
VE-cadherin-2
protocadherin 14
vascular cadherin-2
vascular endothelial cadherin-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017378.2NP_059074.2  protocadherin-12 precursor

    See identical proteins and their annotated locations for NP_059074.2

    Status: VALIDATED

    Source sequence(s)
    AK028374, AK048100, AK165819, Y08715
    Consensus CDS
    CCDS29199.1
    UniProtKB/Swiss-Prot
    G5E847, O55134
    UniProtKB/TrEMBL
    Q8C883
    Related
    ENSMUSP00000025311.6, ENSMUST00000025311.8
    Conserved Domains (2) summary
    cd11304
    Location:251348
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:32111
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    38400145..38417454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)