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Timm23 translocase of inner mitochondrial membrane 23 [ Mus musculus (house mouse) ]

Gene ID: 53600, updated on 11-Apr-2024

Summary

Official Symbol
Timm23provided by MGI
Official Full Name
translocase of inner mitochondrial membrane 23provided by MGI
Primary source
MGI:MGI:1858317
See related
Ensembl:ENSMUSG00000013701 AllianceGenome:MGI:1858317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim23
Summary
Predicted to enable enzyme binding activity and protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in several structures, including central nervous system; lens; orbito-sphenoid; submandibular gland primordium; and tooth. Orthologous to several human genes including TIMM23 (translocase of inner mitochondrial membrane 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 102.6), placenta adult (RPKM 64.7) and 28 other tissues See more
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Genomic context

See Timm23 in Genome Data Viewer
Location:
14 B; 14 19.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31902123..31923848, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32180166..32201891, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene beta-microseminoprotein Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene nuclear receptor coactivator 4 Neighboring gene STARR-seq mESC enhancer starr_36340 Neighboring gene predicted gene, 23946 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene STARR-positive B cell enhancer mm9_chr14:33042212-33042513 Neighboring gene tetratricopeptide repeat domain 35 pseudogene Neighboring gene predicted gene, 48914 Neighboring gene STARR-seq mESC enhancer starr_36341

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC46821

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim23
Names
translocase of inner mitochondrial membrane 23 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016897.3NP_058593.2  mitochondrial import inner membrane translocase subunit Tim23

    See identical proteins and their annotated locations for NP_058593.2

    Status: VALIDATED

    Source sequence(s)
    AK146516, AV345749, BY767660
    Consensus CDS
    CCDS36864.1
    UniProtKB/TrEMBL
    Q8JZQ1, Q9CXU4
    Related
    ENSMUSP00000013845.7, ENSMUST00000013845.13
    Conserved Domains (1) summary
    TIGR00983
    Location:46191
    3a0801s02tim23; mitochondrial import inner membrane translocase subunit tim23

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31902123..31923848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)