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Dctn3 dynactin 3 [ Mus musculus (house mouse) ]

Gene ID: 53598, updated on 12-Aug-2019

Summary

Official Symbol
Dctn3provided by MGI
Official Full Name
dynactin 3provided by MGI
Primary source
MGI:MGI:1859251
See related
Ensembl:ENSMUSG00000028447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p24
Expression
Ubiquitous expression in CNS E18 (RPKM 56.9), CNS E14 (RPKM 43.8) and 28 other tissues See more
Orthologs

Genomic context

See Dctn3 in Genome Data Viewer
Location:
4; 4 A5
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41714798..41723163, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (41661830..41670195, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ciliary neurotrophic factor receptor Neighboring gene ribonuclease P/MRP 25 subunit-like Neighboring gene AT rich interactive domain 3C (BRIGHT-like) Neighboring gene sigma non-opioid intracellular receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton-dependent cytokinesis ISO
Inferred from Sequence Orthology
more info
 
microtubule-based process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dynactin complex IDA
Inferred from Direct Assay
more info
PubMed 
dynactin complex ISO
Inferred from Sequence Orthology
more info
 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynactin subunit 3
Names
dctn3
dynactin light chain (P24)
dynactin light chain p24
p24 dynactin light chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159565.1NP_001153037.1  dynactin subunit 3 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several in-frame segments in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AK011840, AV493721, BY141790
    Consensus CDS
    CCDS51143.1
    UniProtKB/Swiss-Prot
    Q9Z0Y1
    UniProtKB/TrEMBL
    E9Q919
    Related
    ENSMUSP00000130988.1, ENSMUST00000171641.1
    Conserved Domains (1) summary
    pfam07426
    Location:10137
    Dynactin_p22; Dynactin subunit p22
  2. NM_016890.4NP_058586.3  dynactin subunit 3 isoform A

    See identical proteins and their annotated locations for NP_058586.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AK011840, BY141790
    Consensus CDS
    CCDS18069.1
    UniProtKB/Swiss-Prot
    Q9Z0Y1
    Related
    ENSMUSP00000030158.4, ENSMUST00000030158.10
    Conserved Domains (1) summary
    pfam07426
    Location:10170
    Dynactin_p22; Dynactin subunit p22

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p6 C57BL/6J

    Range
    41714798..41723163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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