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Prx2 Peroxiredoxin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53578, updated on 4-Jan-2025

Summary

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Official Symbol
Prx2provided by FlyBase
Official Full Name
Peroxiredoxin 2provided by FlyBase
Primary source
FLYBASE:FBgn0040309
Locus tag
Dmel_CG1633
See related
AllianceGenome:FB:FBgn0040309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1
Summary
Enables thioredoxin-dependent peroxiredoxin activity. Involved in several processes, including cell redox homeostasis; determination of adult lifespan; and hydrogen peroxide catabolic process. Located in cytosol. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; embryonic foregut; germline cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to several human genes including PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Prx2 in Genome Data Viewer
Location:
11E11-11E11; 1-42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13329824..13331994)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13223857..13226027)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45018 Neighboring gene Inositol 1,4,5-triphosphate kinase 2 Neighboring gene long non-coding RNA:CR32636 Neighboring gene Ribosomal protein S15Aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct translation regulation by two alternative 5'UTRs of a stress-responsive protein--dPrx I. Chen CW, et al. J Biomed Sci, 2005 Oct. PMID 16200348
  2. Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells. Radyuk SN, et al. Biochem J, 2003 May 1. PMID 12556226, Free PMC Article
  3. Identification of Targets from LRRK2 Rescue Phenotypes. Toh J, et al. Cells, 2021 Jan 5. PMID 33466414, Free PMC Article
  4. Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2. Bauer H, et al. J Biol Chem, 2002 May 17. PMID 11877442
  5. Evidence of acrylamide-induced behavioral deficit, mitochondrial dysfunction and cell death in Drosophila melanogaster. Farodoye OM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2024 Oct. PMID 38972620

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Jafrac1-mediated reduction of hydrogen peroxide is required to maintain DE-cadherin protein levels in the early embryo.
    Title: Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion.
  2. Activation of JNK/FOXO signaling in neurons increased the Jafrac1 expression level under both normal and oxidative stressed conditions.
    Title: JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.
  3. gene for thioredoxin peroxidase (DmTPx-1) was cloned and expressed, and the protein characterized
    Title: Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-dependent peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-dependent peroxiredoxin activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell redox homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peroxiredoxin 2
Names
CG1633-PA
CG1633-PB
CG1633-PC
CG1633-PD
CG1633-PE
Jafrac-1
Prx2-PA
Prx2-PB
Prx2-PC
Prx2-PD
Prx2-PE
jafrac1
peroxidase
peroxiredoxin
peroxiredoxin 1
peroxiredoxin 4783
peroxiredoxin I
thioredoxin peroxidase
thioredoxin peroxidase 1
NP_001285202.1
NP_001285203.1
NP_001285204.1
NP_477510.1
NP_727689.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13329824..13331994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298274.1 → NP_001285203.1  peroxiredoxin 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285203.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHT0, Q9V3P0
    UniProtKB/TrEMBL
    F6J6B9, X2JF59
    Conserved Domains (1) summary
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  2. NM_167359.2 → NP_727689.1  peroxiredoxin 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727689.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHT0, Q9V3P0
    UniProtKB/TrEMBL
    F6J6B9, X2JF59
    Related
    FBpp0073594
    Conserved Domains (1) summary
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  3. NM_058162.3 → NP_477510.1  peroxiredoxin 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477510.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHT0, Q9V3P0
    UniProtKB/TrEMBL
    F6J6B9, X2JF59
    Related
    FBpp0073595
    Conserved Domains (1) summary
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  4. NM_001298273.1 → NP_001285202.1  peroxiredoxin 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHT0, Q9V3P0
    UniProtKB/TrEMBL
    F6J6B9, X2JF59
    Conserved Domains (1) summary
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  5. NM_001298275.1 → NP_001285204.1  peroxiredoxin 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHT0, Q9V3P0
    UniProtKB/TrEMBL
    F6J6B9, X2JF59
    Conserved Domains (1) summary
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3P0.1 Q9V3P0
X2JF59 X2JF59

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