Jafrac1 thioredoxin peroxidase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Jafrac1provided by FlyBase
Official Full Name: thioredoxin peroxidase 1provided by FlyBase
Primary source: FLYBASE:FBgn0040309
Locus tag: Dmel_CG1633
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPrx I; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; jf1; PRDX1_DROME; Prx; Prx4783; SSP5111; T20

Genomic context

Location:: 11E11-11E11; 1-42 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.13	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13329824..13331994)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13223857..13226027)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Jafrac1-mediated reduction of hydrogen peroxide is required to maintain DE-cadherin protein levels in the early embryo.
Title: Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion.
Activation of JNK/FOXO signaling in neurons increased the Jafrac1 expression level under both normal and oxidative stressed conditions.
Title: JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.
gene for thioredoxin peroxidase (DmTPx-1) was cloned and expressed, and the protein characterized
Title: Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2.

Submit: New GeneRIF Correction

Variation

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Genotypes

See SNP Geneview Report

Pathways from BioSystems

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Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peroxisome, organism-specific biosystem (from KEGG)
Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
Peroxisome, conserved biosystem (from KEGG)
Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
TP53 Regulates Metabolic Genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
Transcriptional Regulation by TP53, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Jafrac1 gene: The Jafrac1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.cerevisiae, S.pombe, A.thaliana, rice, and frog.
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
thioredoxin peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
thioredoxin peroxidase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell redox homeostasis	IDA Inferred from Direct Assay more info	PubMed
determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
oxidation-reduction process	IEA Inferred from Electronic Annotation more info
response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thioredoxin peroxidase 1

Names: CG1633-PA; CG1633-PB; CG1633-PC; CG1633-PD; CG1633-PE; Jafrac1-PA; Jafrac1-PB; Jafrac1-PC; Jafrac1-PD; Jafrac1-PE; peroxidase; peroxiredoxin; peroxiredoxin 1; peroxiredoxin 4783; peroxiredoxin I; thioredoxin peroxidase

NP_001285202.1

EC 1.11.1.-

NP_001285203.1

EC 1.11.1.-

NP_001285204.1

EC 1.11.1.-

NP_477510.1

EC 1.11.1.-

NP_727689.1

EC 1.11.1.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13329824..13331994

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298274.1 → NP_001285203.1 thioredoxin peroxidase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285203.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3P0

UniProtKB/TrEMBL

X2JF59

Related

FBpp0308757.1, FBtr0339700

Conserved Domains (2) summary

PTZ00253
Location:3 → 193

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_167359.2 → NP_727689.1 thioredoxin peroxidase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727689.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3P0

UniProtKB/TrEMBL

X2JF59

Related

FBpp0073594.1, FBtr0073763

Conserved Domains (2) summary

PTZ00253
Location:3 → 193

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_058162.3 → NP_477510.1 thioredoxin peroxidase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477510.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3P0

UniProtKB/TrEMBL

X2JF59

Related

FBpp0073595.1, FBtr0073764

Conserved Domains (2) summary

PTZ00253
Location:3 → 193

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001298273.1 → NP_001285202.1 thioredoxin peroxidase 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285202.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3P0

UniProtKB/TrEMBL

X2JF59

Related

FBpp0308756.1, FBtr0339699

Conserved Domains (2) summary

PTZ00253
Location:3 → 193

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001298275.1 → NP_001285204.1 thioredoxin peroxidase 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285204.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3P0

UniProtKB/TrEMBL

X2JF59

Related

FBpp0311371.1, FBtr0345161

Conserved Domains (2) summary

PTZ00253
Location:3 → 193

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...