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Jafrac1 thioredoxin peroxidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53578, updated on 14-Jan-2021

Summary

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Official Symbol
Jafrac1provided by FlyBase
Official Full Name
thioredoxin peroxidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0040309
Locus tag
Dmel_CG1633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPrx I; dPrx1; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; jf1; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1
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Genomic context

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See Jafrac1 in Genome Data Viewer
Location:
11E11-11E11; 1-42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13329824..13331994)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13223857..13226027)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45018 Neighboring gene Inositol 1,4,5-triphosphate kinase 2 Neighboring gene long non-coding RNA:CR32636 Neighboring gene Ribosomal protein S15Aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct translation regulation by two alternative 5'UTRs of a stress-responsive protein--dPrx I. Chen CW, et al. J Biomed Sci, 2005 Oct. PMID 16200348
  2. A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway. Barata AG, et al. Redox Biol, 2020 Jan. PMID 31629169, Free PMC Article
  3. Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells. Radyuk SN, et al. Biochem J, 2003 May 1. PMID 12556226, Free PMC Article
  4. Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2. Bauer H, et al. J Biol Chem, 2002 May 17. PMID 11877442
  5. TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway. Du EJ, et al. PLoS Genet, 2016 Jan. PMID 26726767, Free PMC Article

See all (97) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Jafrac1-mediated reduction of hydrogen peroxide is required to maintain DE-cadherin protein levels in the early embryo.
    Title: Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion.
  2. Activation of JNK/FOXO signaling in neurons increased the Jafrac1 expression level under both normal and oxidative stressed conditions.
    Title: JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.
  3. gene for thioredoxin peroxidase (DmTPx-1) was cloned and expressed, and the protein characterized
    Title: Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Homologs of the Jafrac1 gene: The Jafrac1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.cerevisiae, S.pombe, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
thioredoxin peroxidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cell redox homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin peroxidase 1
Names
CG1633-PA
CG1633-PB
CG1633-PC
CG1633-PD
CG1633-PE
Jafrac-1
Jafrac1-PA
Jafrac1-PB
Jafrac1-PC
Jafrac1-PD
Jafrac1-PE
jafrac1
peroxidase
peroxiredoxin
peroxiredoxin 1
peroxiredoxin 4783
peroxiredoxin I
thioredoxin peroxidase
NP_001285202.1
NP_001285203.1
NP_001285204.1
NP_477510.1
NP_727689.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13329824..13331994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298274.1 → NP_001285203.1  thioredoxin peroxidase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285203.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3P0
    UniProtKB/TrEMBL
    X2JF59
    Related
    FBpp0308757, FBtr0339700
    Conserved Domains (2) summary
    PTZ00253
    Location:3 → 193
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  2. NM_167359.2 → NP_727689.1  thioredoxin peroxidase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727689.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3P0
    UniProtKB/TrEMBL
    X2JF59
    Related
    FBpp0073594, FBtr0073763
    Conserved Domains (2) summary
    PTZ00253
    Location:3 → 193
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  3. NM_058162.3 → NP_477510.1  thioredoxin peroxidase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477510.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3P0
    UniProtKB/TrEMBL
    X2JF59
    Related
    FBpp0073595, FBtr0073764
    Conserved Domains (2) summary
    PTZ00253
    Location:3 → 193
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  4. NM_001298273.1 → NP_001285202.1  thioredoxin peroxidase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3P0
    UniProtKB/TrEMBL
    X2JF59
    Related
    FBpp0308756, FBtr0339699
    Conserved Domains (2) summary
    PTZ00253
    Location:3 → 193
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  5. NM_001298275.1 → NP_001285204.1  thioredoxin peroxidase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3P0
    UniProtKB/TrEMBL
    X2JF59
    Related
    FBpp0311371, FBtr0345161
    Conserved Domains (2) summary
    PTZ00253
    Location:3 → 193
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:4 → 175
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3P0.1

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