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wun2 wunen-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53558, updated on 23-Jul-2026
Official Symbol
wun2provided by FlyBase
Official Full Name
wunen-2provided by FlyBase
Primary source
FLYBASE:FBgn0041087
Locus tag
Dmel_CG8805
See related
AllianceGenome:FB:FBgn0041087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:CK02248; CG8805; CK02248; Dmel\CG8805; DrPAP2[G]; LPP-like; N14; Pap2G; Tunen; wun-2; WUN-like; Wun2; Wunen-2
Summary
Enables lipid phosphatase activity and lipid transporter activity. Involved in germ cell development; germ cell repulsion; and pole cell development. Located in apical part of cell and plasma membrane. Is expressed in adult head; embryonic/larval midgut primordium; epidermis; hindgut proper primordium; and neuroblasts. Orthologous to several human genes including PLPP1 (phospholipid phosphatase 1) and PLPP2 (phospholipid phosphatase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See wun2 in Genome Data Viewer
Location:
45D4-45D5; 2-60 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9414342..9417846)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5301847..5305351)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lethal (2) k10201 Neighboring gene uncharacterized protein Neighboring gene wunen Neighboring gene uncharacterized protein Neighboring gene preli-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Quantifying the range of a lipid phosphate signal in vivo. Mukherjee A, et al. J Cell Sci, 2013 Dec 1. PMID 24006260
  2. Germ line versus soma: distinction, competition, and interaction. Lehmann R. Harvey Lect, 2005-2006. PMID 18030973
  3. What is left behind--quality control in germ cell migration. Boldajipour B, et al. Sci STKE, 2007 Apr 24. PMID 17456805
  4. Quantitative Differences in a Single Maternal Factor Determine Survival Probabilities among Drosophila Germ Cells. Slaidina M, et al. Curr Biol, 2017 Jan 23. PMID 28065608, Free PMC Article
  5. Follow the fatty brick road: lipid signaling in cell migration. Renault AD, et al. Curr Opin Genet Dev, 2006 Aug. PMID 16806899

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. germ cell survival and directionality of migration are controlled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2). wun wun2 double mutant analysis reveals that the two genes act redundantly in primordial germ cells.
    Title: Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila.
  2. Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2 have roles in lateral migration and germ cell elimination
    Title: Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2.
  3. functions in germ cells, enabling them to perceive the wun/wun2-related signal from the soma
    Title: Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Preferred Names
wunen-2
Names
CG8805-PA
CG8805-PB
Wunen2
wun2-PA
wun2-PB
wunen 2
NP_001286248.1
NP_524991.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9414342..9417846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299319.1 → NP_001286248.1  wunen-2, isoform B

    See identical proteins and their annotated locations for NP_001286248.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEJ6
    Conserved Domains (1) summary
    cd03384
    Location:87 → 242
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  2. NM_080252.4 → NP_524991.1  wunen-2, isoform A

    See identical proteins and their annotated locations for NP_524991.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7U4, Q7KGH1, Q8IGU7, Q9NGZ2
    Related
    FBpp0087590
    Conserved Domains (1) summary
    cd03384
    Location:191 → 346
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEJ6 A0A0B4LEJ6
Q7KGH1 Q7KGH1
Q8IGU7 Q8IGU7
Q9NGZ2 Q9NGZ2

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