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GRB2 growth factor receptor bound protein 2 [ Bos taurus (domestic cattle) ]

Gene ID: 535298, updated on 5-Sep-2025
Official Symbol
GRB2provided by VGNC
Official Full Name
growth factor receptor bound protein 2provided by VGNC
Primary source
VGNC:VGNC:29631
See related
BGD:BT17792; EnsemblRapid:ENSBTAG00070012127
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See GRB2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (56117213..56183327)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene CASK interacting protein 2 Neighboring gene transmembrane protein 94 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC112442779 Neighboring gene solute carrier family 25 member 19 Neighboring gene MIF4G domain containing Neighboring gene mitochondrial ribosomal protein S7

Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC127576

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
growth factor receptor-bound protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034630.1 → NP_001029802.1  growth factor receptor-bound protein 2

    See identical proteins and their annotated locations for NP_001029802.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102411
    UniProtKB/TrEMBL
    A0AAA9TWK5, Q3T0F9
    Related
    ENSBTAP00070016456.1, ENSBTAT00070027445.1
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    56117213..56183327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010816566.3 → XP_010814868.1  growth factor receptor-bound protein 2 isoform X1

    See identical proteins and their annotated locations for XP_010814868.1

    UniProtKB/TrEMBL
    A0AAA9TWK5, Q3T0F9
    Related
    ENSBTAP00070016462.1, ENSBTAT00070027451.1
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  2. XM_024980286.1 → XP_024836054.1  growth factor receptor-bound protein 2 isoform X2

    UniProtKB/TrEMBL
    A0AAA9SNB1
    Related
    ENSBTAP00070016433.1, ENSBTAT00070027422.1
    Conserved Domains (3) summary
    cd09941
    Location:39 → 133
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11949
    Location:143 → 195
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cl17036
    Location:9 → 39
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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