ITGA6 integrin subunit alpha 6 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ITGA6provided by VGNC
Official Full Name: integrin subunit alpha 6provided by VGNC
Primary source: VGNC:VGNC:30318
See related: BGD:BT23925; Ensembl:ENSBTAG00070005117
Gene type: protein coding
RefSeq status: INFERRED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (24091592..24179353, complement)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin alpha 6 homozygous splice-site mutation causes a new form of junctional epidermolysis bullosa in Charolais cattle.
Title: Integrin alpha 6 homozygous splice-site mutation causes a new form of junctional epidermolysis bullosa in Charolais cattle.
integrin alpha6beta4 was indeed involved in dairy cow mammary development.
Title: Up-regulation of integrin α6β4 expression by mitogens involved in dairy cow mammary development.
This study showed a reduced expression of alpha-6 integrin in bovine spermatogonia separated by Percoll density gradient centrifugation.
Title: α-6 integrin expression in bovine spermatogonial cells purified by discontinuous Percoll density gradient.
formation of CD151-integrin complex was likely to be a prerequisite for CD151-induced angiogenesis and signaling pathways
Title: Role of tetraspanin CD151-α3/α6 integrin complex: Implication in angiogenesis CD151-integrin complex in angiogenesis.
The presence of these integrin subunits on the bovine oocyte vitelline membrane supports the hypothesis that sperm-oocyte interactions in the bovine are mediated by integrins.
Title: Specific integrin subunits in bovine oocytes, including novel sequences for alpha 6 and beta 3 subunits.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in leukocyte migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin alpha-6

Names: integrin, alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109981.2 → NP_001103451.1 integrin alpha-6 precursor

See identical proteins and their annotated locations for NP_001103451.1

Status: INFERRED

Source sequence(s)

NKLS02000002

UniProtKB/TrEMBL

A0AAA9SAT9, A0AAA9T5S8

Related

ENSBTAP00070006610.1, ENSBTAT00070011706.1

Conserved Domains (3) summary

smart00191
Location:374 → 425

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1038 → 1052

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:464 → 939

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

Range

24091592..24179353 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005202341.5 → XP_005202398.1 integrin alpha-6 isoform X1

UniProtKB/TrEMBL

A0A3Q1M8K4, A0AAA9T5S8

Related

ENSBTAP00070006613.1, ENSBTAT00070011714.1

Conserved Domains (2) summary

smart00191
Location:374 → 425

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:464 → 939

Integrin_alpha2; Integrin alpha