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LYN LYN proto-oncogene, Src family tyrosine kinase [ Bos taurus (domestic cattle) ]

Gene ID: 534996, updated on 30-Jan-2025
Official Symbol
LYNprovided by VGNC
Official Full Name
LYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:31098
See related
BGD:BT22135; EnsemblRapid:ENSBTAG00070022480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See LYN in Genome Data Viewer
Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (23135370..23244752)

Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 68 Neighboring gene trimethylguanosine synthase 1 Neighboring gene small nucleolar RNA U54 Neighboring gene U1 spliceosomal RNA Neighboring gene ribosomal protein S20

Genomic Sequence:
NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Fc receptor mediated stimulatory signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of mast cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of dendritic cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tolerance induction to self antigen IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase Lyn
Names
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
NP_001171211.2
XP_024857406.1
XP_024857407.1
XP_059749282.1
XP_059749283.1
XP_059749284.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177740.2 → NP_001171211.2  tyrosine-protein kinase Lyn

    Status: VALIDATED

    Source sequence(s)
    EH373958, EV733272, NKLS02000014
    UniProtKB/TrEMBL
    D4QGC1, D6RVQ8, F1N261
    Related
    ENSBTAP00070030229.1, ENSBTAT00070050592.1
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    23135370..23244752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059893299.1 → XP_059749282.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    D4QGC1, D6RVQ8, F1N261

  2. XM_059893301.1 → XP_059749284.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    D4QGC1, D6RVQ8

  3. XM_059893300.1 → XP_059749283.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    D4QGC1, D6RVQ8, F1N261

  4. XM_025001638.2 → XP_024857406.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    D4QGC1, D6RVQ8, F1N261
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  5. XM_025001639.2 → XP_024857407.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    D4QGC1, D6RVQ8
    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
Nucleotide Protein Strain
Heading Accession and Version

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