ARHGAP25 Rho GTPase activating protein 25 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ARHGAP25provided by VGNC
Official Full Name: Rho GTPase activating protein 25provided by VGNC
Primary source: VGNC:VGNC:26083
See related: BGD:BT14087; Ensembl:ENSBTAG00000023976
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (67088758..67183487)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046392.1 → NP_001039857.1 rho GTPase-activating protein 25

See identical proteins and their annotated locations for NP_001039857.1

Status: PROVISIONAL

Source sequence(s)

BC105510

UniProtKB/TrEMBL

Q2KJ55

Related

ENSBTAP00000032931.5, ENSBTAT00000033004.6

Conserved Domains (4) summary

cd04390
Location:156 → 354

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

cd13263
Location:45 → 157

PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain

pfam00169
Location:47 → 150

PH; PH domain

pfam13863
Location:544 → 635

DUF4200; Domain of unknown function (DUF4200)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

Range

67088758..67183487

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015473507.3 → XP_015328993.1 rho GTPase-activating protein 25 isoform X3

Related

ENSBTAP00000079735.1, ENSBTAT00000097381.1

Conserved Domains (4) summary

cd04390
Location:162 → 360

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

cd13263
Location:51 → 163

PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain

pfam00169
Location:53 → 156

PH; PH domain

pfam13863
Location:550 → 641

DUF4200; Domain of unknown function (DUF4200)
XM_010810125.4 → XP_010808427.2 rho GTPase-activating protein 25 isoform X2
XM_005212861.5 → XP_005212918.3 rho GTPase-activating protein 25 isoform X1

Related

ENSBTAP00000092153.1, ENSBTAT00000124072.1
XM_010810126.4 → XP_010808428.1 rho GTPase-activating protein 25 isoform X4

Conserved Domains (3) summary

cd04390
Location:38 → 236

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

pfam10267
Location:341 → 484

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

pfam13863
Location:426 → 517

DUF4200; Domain of unknown function (DUF4200)