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POLA1 DNA polymerase alpha 1, catalytic subunit [ Bos taurus (cattle) ]

Gene ID: 534848, updated on 4-Jul-2020

Summary

Official Symbol
POLA1provided by VGNC
Official Full Name
DNA polymerase alpha 1, catalytic subunitprovided by VGNC
Primary source
VGNC:VGNC:33110
See related
BGD:BT11013; Ensembl:ENSBTAG00000008170
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
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Genomic context

See POLA1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
39
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) X NC_037357.1 (118341176..118636869, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) X AC_000187.1 (125373115..125668607, complement)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Neighboring gene aristaless related homeobox Neighboring gene 60S ribosomal protein L13a pseudogene Neighboring gene small Cajal body-specific RNA 24 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene phosphate cytidylyltransferase 1B, choline Neighboring gene uncharacterized LOC101905398

Genomic regions, transcripts, and products

General gene information

Markers

Homology

Clone Names

  • MGC157406

General protein information

Preferred Names
DNA polymerase alpha catalytic subunit
Names
polymerase (DNA directed), alpha 1, catalytic subunit
NP_001192994.1
XP_005228413.1
XP_005228416.1
XP_005228417.1
XP_024843893.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206065.1NP_001192994.1  DNA polymerase alpha catalytic subunit

    See identical proteins and their annotated locations for NP_001192994.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000030
    Conserved Domains (5) summary
    cd05776
    Location:535767
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:8321242
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:501225
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12651455
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:3595
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    118341176..118636869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005228356.4XP_005228413.1  DNA polymerase alpha catalytic subunit isoform X1

    Related
    ENSBTAP00000010742.5, ENSBTAT00000010742.5
    Conserved Domains (5) summary
    cd05776
    Location:541773
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:8381248
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:561231
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12711461
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:41101
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
  2. XM_024988125.1XP_024843893.1  DNA polymerase alpha catalytic subunit isoform X4

    Conserved Domains (2) summary
    TIGR00592
    Location:561231
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12711388
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
  3. XM_005228359.4XP_005228416.1  DNA polymerase alpha catalytic subunit isoform X2

    Related
    ENSBTAP00000058034.1, ENSBTAT00000086475.1
    Conserved Domains (5) summary
    cd05776
    Location:541773
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:8381248
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:561231
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12711388
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:41101
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
  4. XM_005228360.4XP_005228417.1  DNA polymerase alpha catalytic subunit isoform X3

    Conserved Domains (5) summary
    cd05776
    Location:541773
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:8381248
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:561231
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12711392
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:41101
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
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