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TOP1 DNA topoisomerase I [ Bos taurus (cattle) ]

Gene ID: 534799, updated on 27-Aug-2018

Summary

Official Symbol
TOP1provided by VGNC
Official Full Name
DNA topoisomerase Iprovided by VGNC
Primary source
VGNC:VGNC:49136
See related
BGD:BT10591; Ensembl:ENSBTAG00000007960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

See TOP1 in Genome Data Viewer
Location:
13q22-q23
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 13 NC_037340.1 (69684979..69780576)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 13 AC_000170.1 (70383808..70481490)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene uncharacterized LOC112449380 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC101907320 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene phospholipase C gamma 1

Genomic regions, transcripts, and products

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

General protein information

Preferred Names
DNA topoisomerase 1
Names
topoisomerase (DNA) 1
topoisomerase (DNA) I
NP_001193416.1
XP_024856484.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206487.2NP_001193416.1  DNA topoisomerase 1

    See identical proteins and their annotated locations for NP_001193416.1

    Status: VALIDATED

    Source sequence(s)
    BC118461, DV927671, EE228015, EE351723, EE369776, EH133197, NKLS02000013
    UniProtKB/TrEMBL
    F1MN93, Q17QA9
    Related
    ENSBTAP00000010466.3, ENSBTAT00000010466.3
    Conserved Domains (2) summary
    smart00435
    Location:364741
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:220434
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    69684979..69780576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000716.1XP_024856484.1  DNA topoisomerase 1 isoform X1

    Conserved Domains (2) summary
    smart00435
    Location:114491
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:1184
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
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