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ACVRL1 activin A receptor like type 1 [ Bos taurus (domestic cattle) ]

Gene ID: 534536, updated on 5-Sep-2025
Official Symbol
ACVRL1provided by VGNC
Official Full Name
activin A receptor like type 1provided by VGNC
Primary source
VGNC:VGNC:25597
See related
BGD:BT11850; EnsemblRapid:ENSBTAG00070032716
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See ACVRL1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (27943345..27957129, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene activin A receptor type 1B Neighboring gene ankyrin repeat domain 33 Neighboring gene fidgetin like 2

Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells. Curado F, et al. Mol Cell Biol, 2014 Dec. PMID 25266657, Free PMC Article
  2. Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells. Shao ES, et al. Blood, 2009 Sep 3. PMID 19506300, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that ALK5 and ALK1 play antagonistic roles in TGF-beta-induced podosome formation in aortic endothelial cells.
    Title: ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
  2. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.
    Title: Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC139457

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BMP receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
activin receptor type-1-like
Names
activin A receptor type II-like 1
serine/threonine-protein kinase receptor R3
NP_001076948.1
XP_010803213.1
XP_059742533.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083479.1 → NP_001076948.1  activin receptor type-1-like precursor

    See identical proteins and their annotated locations for NP_001076948.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123398
    UniProtKB/TrEMBL
    A4FUX2, F1MIW7
    Related
    ENSBTAP00070045040.1, ENSBTAT00070073935.1
    Conserved Domains (4) summary
    cd14142
    Location:196 → 493
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:202 → 489
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:173 → 200
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:33 → 103
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27943345..27957129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010804911.4 → XP_010803213.1  activin receptor type-1-like isoform X1

    See identical proteins and their annotated locations for XP_010803213.1

    UniProtKB/TrEMBL
    F1MIW7
    Conserved Domains (3) summary
    cd14142
    Location:196 → 493
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:173 → 200
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:34 → 96
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  2. XM_059886550.1 → XP_059742533.1  activin receptor type-1-like isoform X1

    UniProtKB/TrEMBL
    F1MIW7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials