U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Roc1b Regulator of cullins 1b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53445, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Roc1bprovided by FlyBase
Official Full Name
Regulator of cullins 1bprovided by FlyBase
Primary source
FLYBASE:FBgn0040291
Locus tag
Dmel_CG16988
See related
AllianceGenome:FB:FBgn0040291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT21612; CG16988; Dmel\CG16988; dRoc1b; Roc; roc1b; ROC1b; ROC1B; Roc2; ROC2
Summary
Enables cullin family protein binding activity and ubiquitin protein ligase activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; lipid storage; and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. Is expressed in organism and wing disc. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
61C1-61C1; 3-0.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (357981..358486)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (357981..358486)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase Meg Neighboring gene methuselah Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene trachealess Neighboring gene long non-coding RNA:CR45378

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Noureddine MA, et al. Dev Cell, 2002 Jun. PMID 12062088
  2. RING finger specificity in SCF-driven protein destruction. Jin J, et al. Dev Cell, 2002 Jun. PMID 12062077
  3. Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases. Donaldson TD, et al. Mol Biol Cell, 2004 Nov. PMID 15331761, Free PMC Article
  4. Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping. Reynolds PJ, et al. PLoS One, 2008 Aug 13. PMID 18698375, Free PMC Article
  5. A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila. Arama E, et al. PLoS Biol, 2007 Oct. PMID 17880263, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NEDD8 ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein neddylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
regulator of cullins 1b
Names
CG16988-PA
Roc1b-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    357981..358486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144356.3 → NP_652613.1  regulator of cullins 1b [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652613.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NHX0, Q9W0R1
    Related
    FBpp0072446
    Conserved Domains (2) summary
    pfam12678
    Location:36 → 112
    zf-rbx1; RING-H2 zinc finger
    cl17238
    Location:35 → 122
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NHX0.2 Q9NHX0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous