Atoh7 atonal bHLH transcription factor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atoh7provided by MGI
Official Full Name: atonal bHLH transcription factor 7provided by MGI
Primary source: MGI:MGI:1355553
See related: Ensembl:ENSMUSG00000036816 AllianceGenome:MGI:1355553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Math5; bHLHa13
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in entrainment of circadian clock by photoperiod. Acts upstream of or within circadian rhythm; entrainment of circadian clock; and neural retina development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in persistent hyperplastic primary vitreous. Orthologous to human ATOH7 (atonal bHLH transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 1.7), cortex adult (RPKM 0.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.54 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62935564..62937059)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (63099785..63101280)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atonal homolog 7 (ATOH7) confers neuroprotection for photoreceptor cells in glaucoma via inhibition of the notch pathway.
Title: Atonal homolog 7 (ATOH7) confers neuroprotection for photoreceptor cells in glaucoma via inhibition of the notch pathway.
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas.
Title: Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas.
Study identifies four CSL binding sites within the Atoh7 proximal regulatory region and demonstrates the Rbpj protein interaction at these sequences to regulate its transcription.
Title: Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.
The transient features of Atoh7 protein expression during retinal neurogenesis match the expected pattern at the tissue and cellular level.
Title: The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody.
Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate in ATOH7 deficient mice
Title: Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.
This study present evidence for a Pax6-Atoh7-Eya2 pathway that acts downstream of Atoh7 but upstream of differentiation factor Pou4f2.
Title: Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation.
Notch signaling controls the overall tempo of retinogenesis through Atoh7 and Neurog2, by integrating cell fate specification, the wave of neurogenesis and the developmental status of cells ahead of this wave
Title: Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina.
The level of basic helix-loop-helix factor Math5 expression may determine the ultimate number of retinal ganglion cells.
Title: Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis.
Atoh7 acts dominantly in Neurod1-expressing retina progenitor cells to activate the retinal ganglion cell genetic program.
Title: Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7.
Results suggest that Math5 is not sufficient to stimulate retinal ganglion cell (RGC)fate.
Title: Pushing the envelope of retinal ganglion cell genesis: context dependent function of Math5 (Atoh7).

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Atoh7 (e-PCR), detects polymorphism
- UniSTS:164868

NoName (e-PCR)
- UniSTS:494177

NoName (e-PCR)
- UniSTS:489204

Atoh7 (e-PCR), detects polymorphism
- UniSTS:536829

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural retina development	ISO Inferred from Sequence Orthology more info
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within optic nerve development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auditory stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor Atoh7

Names: helix-loop-helix protein mATH-5; protein atonal homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364648.2 → NP_001351577.1 transcription factor Atoh7 isoform 2

Status: VALIDATED

Source sequence(s)

AC155909

Conserved Domains (1) summary

smart00353
Location:54 → 99

HLH; helix loop helix domain
NM_016864.3 → NP_058560.1 transcription factor Atoh7 isoform 1

See identical proteins and their annotated locations for NP_058560.1

Status: VALIDATED

Source sequence(s)

AC155909

Consensus CDS

CCDS23896.1

UniProtKB/Swiss-Prot

Q9Z2E5

Related

ENSMUSP00000039801.4, ENSMUST00000044059.5

Conserved Domains (1) summary

smart00353
Location:54 → 99

HLH; helix loop helix domain