Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpa2b1provided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein A2/B1provided by MGI
Primary source: MGI:MGI:104819
See related: Ensembl:ENSMUSG00000004980 AllianceGenome:MGI:104819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpa2; hnrnp-A; Hnrpa2b1; 9130414A06Rik
Summary: Enables pre-mRNA intronic binding activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 290.0), liver E14 (RPKM 181.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 B3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (51437414..51448054, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (51460434..51470048, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis.
Title: Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis.
Interaction of tau with HNRNPA2B1 and N(6)-methyladenosine RNA mediates the progression of tauopathy.
Title: Interaction of tau with HNRNPA2B1 and N(6)-methyladenosine RNA mediates the progression of tauopathy.
Functional roles of hnRNPA2/B1 regulated by METTL3 in mammalian embryonic development.
Title: Functional roles of hnRNPA2/B1 regulated by METTL3 in mammalian embryonic development.
Our data suggested that HCMV. ie2 promotes glioblastoma migration by regulating hnRNP A2B1 expression
Title: Human cytomegalovirus ie2 affects the migration of glioblastoma by mediating the different splicing patterns of RON through hnRNP A2B1.
hnRNPA2B1 plays important roles in initiating IFN-alpha/beta production and enhancing stimulator of interferon genes (STING)-dependent cytoplasmic antiviral signaling.
Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
HnRNP A2/B1 loss results in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (ALS)-associated D-amino acid oxidase (DAO) that reduces D-serine metabolism.
Title: Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.
A1 and A2/B1, which are required for transcript degradation
Title: A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.
Findings suggest that hnRNP A2/B1 has an important role in regulation of the innate immune system, especially at the level of monocyte/macrophage activation.
Title: Inhibition of Inflammation and Bone Erosion by RNA Interference-Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis.
hnRNPA2/B1 plays a functional role in SMC differentiation from stem cells in vitro and embryonic branchial arch artery development.
Title: Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis.
splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression
Title: The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Hnrnpa2b1 gene: The Hnrnpa2b1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 348 organisms have orthologs with human gene Hnrnpa2b1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA intronic binding	IDA Inferred from Direct Assay more info	PubMed
enables regulatory region RNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G-quadruplex DNA unwinding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in RNA transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in miRNA transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of telomerase RNA reverse transcriptase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in telomere capping	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoproteins A2/B1

Names: heterogenous nuclear ribonucleoprotein A2/B1; hnRNP A2/B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374745.1 → NP_001361674.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (3).

Source sequence(s)

AC154011

Consensus CDS

CCDS90046.1

UniProtKB/Swiss-Prot

Q9R204

UniProtKB/TrEMBL

A0A6P5PV16, A0A8C6MTV5

Conserved Domains (3) summary

pfam11627
Location:302 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
NM_016806.3 → NP_058086.2 heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1

See identical proteins and their annotated locations for NP_058086.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK035626, AK137214, BB627924, BC141253, CN665325

Consensus CDS

CCDS51774.1

UniProtKB/Swiss-Prot

O88569

UniProtKB/TrEMBL

A0A6P5PPR8, A0A8C6GWS7

Conserved Domains (3) summary

pfam11627
Location:290 → 314

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
NM_182650.4 → NP_872591.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform 2

See identical proteins and their annotated locations for NP_872591.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AK035626, AK137214, BC141253

Consensus CDS

CCDS51773.1

UniProtKB/Swiss-Prot

O88569

Related

ENSMUSP00000067491.7, ENSMUST00000069949.13

Conserved Domains (3) summary

pfam11627
Location:247 → 274

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

RNA

NR_104468.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK035626, AK137214, BB627924, BC141253

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

51437414..51448054 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166280.1 → XP_036022173.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

Related

ENSMUSP00000145383.2, ENSMUST00000204158.3

Conserved Domains (3) summary

pfam11627
Location:247 → 274

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_030255496.2 → XP_030111356.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

UniProtKB/TrEMBL

A0A6P5PPR8, A0A8C6GWS7

Related

ENSMUSP00000087453.8, ENSMUST00000090002.10

Conserved Domains (3) summary

pfam11627
Location:290 → 314

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_006506373.5 → XP_006506436.2 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

See identical proteins and their annotated locations for XP_006506436.2

UniProtKB/Swiss-Prot

O88569, Q9R204

UniProtKB/TrEMBL

A0A6P5PV16, A0A8C6MTV5

Related

ENSMUSP00000145028.2, ENSMUST00000203954.3

Conserved Domains (3) summary

pfam11627
Location:302 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_030255499.2 → XP_030111359.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

UniProtKB/TrEMBL

A0A6P5Q121, A0A8C6GVH8

Conserved Domains (3) summary

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

pfam11627
Location:259 → 283

HnRNPA1; Nuclear factor hnRNPA1
XM_030255500.2 → XP_030111360.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

Related

ENSMUSP00000145245.2, ENSMUST00000204188.3

Conserved Domains (3) summary

pfam11627
Location:247 → 274

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_036166279.1 → XP_036022172.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

UniProtKB/TrEMBL

A0A6P5PPR8, A0A8C6GWS7

Related

ENSMUSP00000145374.2, ENSMUST00000203220.3

Conserved Domains (3) summary

pfam11627
Location:290 → 314

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_036166278.1 → XP_036022171.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

UniProtKB/Swiss-Prot

Q9R204

UniProtKB/TrEMBL

A0A6P5PV16, A0A8C6MTV5

Related

ENSMUSP00000110103.3, ENSMUST00000114459.8

Conserved Domains (3) summary

pfam11627
Location:302 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_030255497.2 → XP_030111357.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

UniProtKB/TrEMBL

A0A6P5Q121, A0A8C6GVH8

Conserved Domains (3) summary

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

pfam11627
Location:259 → 283

HnRNPA1; Nuclear factor hnRNPA1
XM_030255498.2 → XP_030111358.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

UniProtKB/TrEMBL

A0A6P5Q121, A0A8C6GVH8

Conserved Domains (3) summary

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

pfam11627
Location:259 → 283

HnRNPA1; Nuclear factor hnRNPA1