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Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Mus musculus (house mouse) ]

Gene ID: 53379, updated on 1-Mar-2024

Summary

Official Symbol
Hnrnpa2b1provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein A2/B1provided by MGI
Primary source
MGI:MGI:104819
See related
Ensembl:ENSMUSG00000004980 AllianceGenome:MGI:104819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpa2; hnrnp-A; Hnrpa2b1; 9130414A06Rik
Summary
Enables pre-mRNA intronic binding activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 290.0), liver E14 (RPKM 181.3) and 16 other tissues See more
Orthologs
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Genomic context

See Hnrnpa2b1 in Genome Data Viewer
Location:
6 B3; 6 24.87 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (51437414..51448054, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (51460434..51470048, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:51333989-51334289 Neighboring gene predicted gene 6559 Neighboring gene STARR-seq mESC enhancer starr_15870 Neighboring gene STARR-seq mESC enhancer starr_15871 Neighboring gene nuclear factor, erythroid derived 2, like 3 Neighboring gene STARR-seq mESC enhancer starr_15873 Neighboring gene chromobox 3 Neighboring gene STARR-seq mESC enhancer starr_15875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:51459345-51459528 Neighboring gene STARR-seq mESC enhancer starr_15881 Neighboring gene sorting nexin 10 Neighboring gene predicted gene, 52883 Neighboring gene predicted gene, 53331

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables N6-methyladenosine-containing RNA reader activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA intronic binding IDA
Inferred from Direct Assay
more info
PubMed 
enables regulatory region RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G-quadruplex DNA unwinding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere capping ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoproteins A2/B1
Names
heterogenous nuclear ribonucleoprotein A2/B1
hnRNP A2/B1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374745.1NP_001361674.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (3).
    Source sequence(s)
    AC154011
    Consensus CDS
    CCDS90046.1
    UniProtKB/Swiss-Prot
    B9EJ02, O88569, Q3UVJ5, Q6PCV9, Q8C2A0, Q8CJ71, Q91ZR9, Q9R204
    UniProtKB/TrEMBL
    B7ZP22
    Conserved Domains (3) summary
    pfam11627
    Location:302326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  2. NM_016806.3NP_058086.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1

    See identical proteins and their annotated locations for NP_058086.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK035626, AK137214, BB627924, BC141253, CN665325
    Consensus CDS
    CCDS51774.1
    UniProtKB/TrEMBL
    B7ZP22
    Conserved Domains (3) summary
    pfam11627
    Location:290314
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  3. NM_182650.4NP_872591.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform 2

    See identical proteins and their annotated locations for NP_872591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK035626, AK137214, BC141253
    Consensus CDS
    CCDS51773.1
    UniProtKB/TrEMBL
    B7ZP22
    Related
    ENSMUSP00000067491.7, ENSMUST00000069949.13
    Conserved Domains (3) summary
    pfam11627
    Location:247274
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

RNA

  1. NR_104468.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK035626, AK137214, BB627924, BC141253

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    51437414..51448054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166280.1XP_036022173.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

    UniProtKB/TrEMBL
    B7ZP22
    Related
    ENSMUSP00000145383.2, ENSMUST00000204158.3
    Conserved Domains (3) summary
    pfam11627
    Location:247274
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  2. XM_030255496.2XP_030111356.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

    UniProtKB/TrEMBL
    B7ZP22
    Related
    ENSMUSP00000087453.8, ENSMUST00000090002.10
    Conserved Domains (3) summary
    pfam11627
    Location:290314
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  3. XM_006506373.5XP_006506436.2  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

    See identical proteins and their annotated locations for XP_006506436.2

    UniProtKB/Swiss-Prot
    B9EJ02, O88569, Q3UVJ5, Q6PCV9, Q8C2A0, Q8CJ71, Q91ZR9, Q9R204
    UniProtKB/TrEMBL
    B7ZP22
    Related
    ENSMUSP00000145028.2, ENSMUST00000203954.3
    Conserved Domains (3) summary
    pfam11627
    Location:302326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  4. XM_030255499.2XP_030111359.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

    UniProtKB/TrEMBL
    B7ZP22
    Conserved Domains (3) summary
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:259283
    HnRNPA1; Nuclear factor hnRNPA1
  5. XM_030255500.2XP_030111360.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

    UniProtKB/TrEMBL
    B7ZP22
    Related
    ENSMUSP00000145245.2, ENSMUST00000204188.3
    Conserved Domains (3) summary
    pfam11627
    Location:247274
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  6. XM_036166279.1XP_036022172.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

    UniProtKB/TrEMBL
    B7ZP22
    Related
    ENSMUSP00000145374.2, ENSMUST00000203220.3
    Conserved Domains (3) summary
    pfam11627
    Location:290314
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:100179
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:787
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  7. XM_036166278.1XP_036022171.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

    UniProtKB/Swiss-Prot
    B9EJ02, O88569, Q3UVJ5, Q6PCV9, Q8C2A0, Q8CJ71, Q91ZR9, Q9R204
    UniProtKB/TrEMBL
    B7ZP22
    Related
    ENSMUSP00000110103.3, ENSMUST00000114459.8
    Conserved Domains (3) summary
    pfam11627
    Location:302326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
  8. XM_030255497.2XP_030111357.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

    UniProtKB/TrEMBL
    B7ZP22
    Conserved Domains (3) summary
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:259283
    HnRNPA1; Nuclear factor hnRNPA1
  9. XM_030255498.2XP_030111358.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

    UniProtKB/TrEMBL
    B7ZP22
    Conserved Domains (3) summary
    cd12581
    Location:112191
    RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    cd12762
    Location:1999
    RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    pfam11627
    Location:259283
    HnRNPA1; Nuclear factor hnRNPA1

RNA

  1. XR_377482.5 RNA Sequence

  2. XR_003956232.2 RNA Sequence

  3. XR_003956229.2 RNA Sequence

  4. XR_003956228.1 RNA Sequence

  5. XR_377483.5 RNA Sequence

  6. XR_003956231.2 RNA Sequence

  7. XR_003956230.2 RNA Sequence

  8. XR_004942983.1 RNA Sequence

  9. XR_868868.3 RNA Sequence

  10. XR_004942981.1 RNA Sequence

  11. XR_868866.3 RNA Sequence

  12. XR_868865.3 RNA Sequence

  13. XR_868864.3 RNA Sequence

  14. XR_004942982.1 RNA Sequence