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PAK1 p21 (RAC1) activated kinase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 533729, updated on 5-Sep-2025
Official Symbol
PAK1provided by VGNC
Official Full Name
p21 (RAC1) activated kinase 1provided by VGNC
Primary source
VGNC:VGNC:53657
See related
BGD:BT21063; EnsemblRapid:ENSBTAG00070017316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See PAK1 in Genome Data Viewer
Location:
chromosome: 29
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (18521574..18682812)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene aquaporin 11 Neighboring gene dynein axonemal light chain 1-like Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene glycerophosphodiester phosphodiesterase domain-containing protein 4

Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC139676

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
serine/threonine-protein kinase PAK 1
Names
PAK-1
alpha-PAK
p21-activated kinase 1
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
p65-PAK
NP_001070366.1
XP_010819137.1
XP_010819138.1
XP_010819139.1
XP_015316619.1
XP_024842975.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076898.1 → NP_001070366.1  serine/threonine-protein kinase PAK 1

    See identical proteins and their annotated locations for NP_001070366.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123416
    UniProtKB/Swiss-Prot
    Q08E52
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    18521574..18682812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010820835.3 → XP_010819137.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_010819137.1

    UniProtKB/Swiss-Prot
    Q08E52
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  2. XM_015461133.3 → XP_015316619.1  serine/threonine-protein kinase PAK 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08E52
    Related
    ENSBTAP00070023179.1, ENSBTAT00070039054.1
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  3. XM_010820837.3 → XP_010819139.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_010819139.1

    UniProtKB/Swiss-Prot
    Q08E52
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  4. XM_024987207.2 → XP_024842975.1  serine/threonine-protein kinase PAK 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08E52
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  5. XM_010820836.4 → XP_010819138.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_010819138.1

    UniProtKB/Swiss-Prot
    Q08E52
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08E52.1 GenPept UniProtKB/Swiss-Prot:Q08E52

Gene LinkOut

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