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PTPN11 protein tyrosine phosphatase non-receptor type 11 [ Bos taurus (domestic cattle) ]

Gene ID: 533590, updated on 30-Jan-2025
Official Symbol
PTPN11provided by VGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 11provided by VGNC
Primary source
VGNC:VGNC:33530
See related
BGD:BT23074; EnsemblRapid:ENSBTAG00070025958
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SHP2
Orthologs
human mouse all
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See PTPN11 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (61731486..61802148, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene 2',5'-oligoadenylate synthetase 1, 40/46kDa Neighboring gene rabphilin 3A Neighboring gene U6 spliceosomal RNA Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene ribosomal protein L6 Neighboring gene small nucleolar RNA SNORA79

Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Role of protein tyrosine phosphatase SHP2 in barrier function of pulmonary endothelium. Grinnell KL, et al. Am J Physiol Lung Cell Mol Physiol, 2010 Mar. PMID 20023173, Free PMC Article
  2. Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells. Kusano K, et al. Endothelium, 2008 May-Jun. PMID 18568953, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein phosphatase non-receptor type 11
XP_002694636.2
XP_059732383.1
XP_059732384.1
XP_059732385.1

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    61731486..61802148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059876402.1 → XP_059732385.1  tyrosine-protein phosphatase non-receptor type 11 isoform X4

    UniProtKB/TrEMBL
    A0AAA9ST00, F1N339
    Related
    ENSBTAP00070034938.1, ENSBTAT00070058816.1

  2. XM_059876401.1 → XP_059732384.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

    UniProtKB/TrEMBL
    A0AAA9ST00

  3. XM_002694590.7 → XP_002694636.2  tyrosine-protein phosphatase non-receptor type 11 isoform X3

    See identical proteins and their annotated locations for XP_002694636.2

    UniProtKB/TrEMBL
    A0AAA9ST00
    Related
    ENSBTAP00070034955.1, ENSBTAT00070058844.1
    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

  4. XM_059876400.1 → XP_059732383.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    UniProtKB/TrEMBL
    A0AAA9ST00

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001192779.1: Suppressed sequence

    Description
    NM_001192779.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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