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SHC3 SHC adaptor protein 3 [ Homo sapiens (human) ]

Gene ID: 53358, updated on 7-Jun-2020

Summary

Official Symbol
SHC3provided by HGNC
Official Full Name
SHC adaptor protein 3provided by HGNC
Primary source
HGNC:HGNC:18181
See related
Ensembl:ENSG00000148082 MIM:605263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI; NSHC; SHCC; N-Shc
Expression
Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.7) and 2 other tissues See more
Orthologs

Genomic context

See SHC3 in Genome Data Viewer
Location:
9q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (89005771..89182402, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91620686..91793682, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene PEST containing nuclear protein pseudogene 2 Neighboring gene chromosome 9 open reading frame 47 Neighboring gene sphingosine-1-phosphate receptor 3 Neighboring gene uncharacterized LOC105376136 Neighboring gene microRNA 3153 Neighboring gene CDC28 protein kinase regulatory subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
tat HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45325, DKFZp686H1544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SHC-transforming protein 3
Names
SH2 domain protein C3
SHC (Src homology 2 domain containing) transforming protein 3
SHC-transforming protein C
Shc3 p51
neuronal Shc
protein Rai
src homology 2 domain-containing transforming protein C3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016848.6NP_058544.3  SHC-transforming protein 3

    See identical proteins and their annotated locations for NP_058544.3

    Status: VALIDATED

    Source sequence(s)
    AL160054, AL353150, AL772202, BC026314, D84361
    Consensus CDS
    CCDS6681.1
    UniProtKB/Swiss-Prot
    Q92529
    Related
    ENSP00000364995.4, ENST00000375835.9
    Conserved Domains (2) summary
    cd09925
    Location:492594
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:139310
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    89005771..89182402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518785.3XP_011517087.1  SHC-transforming protein 3 isoform X1

    Conserved Domains (2) summary
    cd09925
    Location:496598
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:139310
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  2. XM_011518786.3XP_011517088.1  SHC-transforming protein 3 isoform X2

    Conserved Domains (2) summary
    cd09925
    Location:350452
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36164
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  3. XM_017014810.2XP_016870299.1  SHC-transforming protein 3 isoform X4

  4. XM_017014809.2XP_016870298.1  SHC-transforming protein 3 isoform X3

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