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PANK1 pantothenate kinase 1 [ Homo sapiens (human) ]

Gene ID: 53354, updated on 17-Dec-2019

Summary

Official Symbol
PANK1provided by HGNC
Official Full Name
pantothenate kinase 1provided by HGNC
Primary source
HGNC:HGNC:8598
See related
Ensembl:ENSG00000152782 MIM:606160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PANK
Summary
This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]
Expression
Broad expression in liver (RPKM 8.6), kidney (RPKM 7.3) and 16 other tissues See more
Orthologs

Genomic context

See PANK1 in Genome Data Viewer
Location:
10q23.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (89579495..89645572, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91339254..91405329, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984251 Neighboring gene interferon induced protein with tetratricopeptide repeats 5 Neighboring gene solute carrier family 16 member 12 Neighboring gene SLC16A12 antisense RNA 1 Neighboring gene microRNA 107 Neighboring gene uncharacterized LOC105378421 Neighboring gene tigger transposable element derived 2 pseudogene Neighboring gene kinesin family member 20B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of pantothenate kinase 1 (PANK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular pantothenate kinase 1 protein (PANK1) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24596

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acetyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
coenzyme biosynthetic process TAS
Traceable Author Statement
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell periphery IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pantothenate kinase 1
Names
pantothenic acid kinase 1
NP_612189.2
NP_683878.1
NP_683879.1
XP_016871822.1
XP_016871823.1
XP_016871824.1
XP_016871825.1
XP_016871826.1
XP_016871827.1
XP_024303808.1
XP_024303809.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029474.1 RefSeqGene

    Range
    5001..71076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138316.4NP_612189.2  pantothenate kinase 1 isoform gamma

    See identical proteins and their annotated locations for NP_612189.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma) differs in the 5' UTR, lacks a portion of the 5' coding region and an internal coding exon, and initiates translation at an alternate start codon, compared to variant alpha. The encoded isoform (gamma) has a distinct N-terminus and is shorter than isoform alpha.
    Source sequence(s)
    AL157400
    Consensus CDS
    CCDS7405.1
    UniProtKB/Swiss-Prot
    Q8TE04
    Related
    ENSP00000318526.6, ENST00000322191.10
    Conserved Domains (1) summary
    pfam03630
    Location:14303
    Fumble; Fumble
  2. NM_148977.2NP_683878.1  pantothenate kinase 1 isoform alpha

    See identical proteins and their annotated locations for NP_683878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AL157400, AY027661, BK000008
    Consensus CDS
    CCDS31244.1
    UniProtKB/Swiss-Prot
    Q8TE04
    Related
    ENSP00000302108.4, ENST00000307534.8
    Conserved Domains (1) summary
    pfam03630
    Location:239587
    Fumble; Fumble
  3. NM_148978.3NP_683879.1  pantothenate kinase 1 isoform beta

    See identical proteins and their annotated locations for NP_683879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant alpha. The encoded isoform (beta) has a distinct N-terminus and is shorter than isoform alpha.
    Source sequence(s)
    AL157400, AY027662
    Consensus CDS
    CCDS7406.1
    UniProtKB/Swiss-Prot
    Q8TE04
    Related
    ENSP00000345118.3, ENST00000342512.3
    Conserved Domains (1) summary
    pfam03630
    Location:14362
    Fumble; Fumble

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    89579495..89645572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016338.1XP_016871827.1  pantothenate kinase 1 isoform X6

    UniProtKB/Swiss-Prot
    Q8TE04
    Conserved Domains (1) summary
    cl17037
    Location:1126
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_024448040.1XP_024303808.1  pantothenate kinase 1 isoform X3

    Conserved Domains (1) summary
    pfam03630
    Location:12360
    Fumble; Fumble
  3. XM_017016337.1XP_016871826.1  pantothenate kinase 1 isoform X5

    Conserved Domains (1) summary
    pfam03630
    Location:1347
    Fumble
  4. XM_017016333.2XP_016871822.1  pantothenate kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8TE04
    Conserved Domains (1) summary
    pfam03630
    Location:41389
    Fumble; Fumble
  5. XM_017016334.1XP_016871823.1  pantothenate kinase 1 isoform X2

  6. XM_017016335.1XP_016871824.1  pantothenate kinase 1 isoform X3

    Conserved Domains (1) summary
    pfam03630
    Location:12360
    Fumble; Fumble
  7. XM_024448041.1XP_024303809.1  pantothenate kinase 1 isoform X3

    Conserved Domains (1) summary
    pfam03630
    Location:12360
    Fumble; Fumble
  8. XM_017016336.1XP_016871825.1  pantothenate kinase 1 isoform X4

    Conserved Domains (1) summary
    pfam03630
    Location:10358
    Fumble; Fumble
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