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PANK1 pantothenate kinase 1 [ Homo sapiens (human) ]

Gene ID: 53354, updated on 2-May-2024

Summary

Official Symbol
PANK1provided by HGNC
Official Full Name
pantothenate kinase 1provided by HGNC
Primary source
HGNC:HGNC:8598
See related
Ensembl:ENSG00000152782 MIM:606160; AllianceGenome:HGNC:8598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PANK
Summary
This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]
Expression
Broad expression in liver (RPKM 8.6), kidney (RPKM 7.3) and 16 other tissues See more
Orthologs
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Genomic context

Location:
10q23.31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89579495..89645242, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90463392..90529134, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91339252..91404999, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3752 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:91181772-91182971 Neighboring gene interferon induced protein with tetratricopeptide repeats 5 Neighboring gene solute carrier family 16 member 12 Neighboring gene SLC16A12 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:91236124-91236624 Neighboring gene NANOG hESC enhancer GRCh37_chr10:91250383-91250884 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:91293618-91294517 Neighboring gene OCT4 hESC enhancer GRCh37_chr10:91318626-91319150 Neighboring gene microRNA 107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:91396001-91396502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2594 Neighboring gene PANK1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:91453141-91453642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2595 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:91460993-91461508 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:91461509-91462025 Neighboring gene tigger transposable element derived 2 pseudogene Neighboring gene kinesin family member 20B Neighboring gene NANOG hESC enhancer GRCh37_chr10:91500841-91501342

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of pantothenate kinase 1 (PANK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular pantothenate kinase 1 protein (PANK1) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC24596

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pantothenate kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pantothenate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in coenzyme A biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pantothenate kinase 1
Names
pantothenic acid kinase 1
NP_612189.2
NP_683878.2
NP_683879.1
XP_016871822.1
XP_016871823.1
XP_016871825.1
XP_047281310.1
XP_054222068.1
XP_054222069.1
XP_054222070.1
XP_054222071.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029474.1 RefSeqGene

    Range
    5331..67585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138316.4NP_612189.2  pantothenate kinase 1 isoform gamma

    See identical proteins and their annotated locations for NP_612189.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma) differs in the 5' UTR, lacks a portion of the 5' coding region and an internal coding exon, and initiates translation at an alternate start codon, compared to variant alpha. The encoded isoform (gamma) has a distinct N-terminus and is shorter than isoform alpha.
    Source sequence(s)
    AL157400
    Consensus CDS
    CCDS7405.1
    UniProtKB/Swiss-Prot
    Q8TE04
    Related
    ENSP00000318526.6, ENST00000322191.10
    Conserved Domains (1) summary
    pfam03630
    Location:14303
    Fumble
  2. NM_148977.3NP_683878.2  pantothenate kinase 1 isoform alpha

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AL157400
    Consensus CDS
    CCDS31244.2
    UniProtKB/TrEMBL
    A0A8C8KBT8, B3KWN3
    Related
    ENSP00000302108.5, ENST00000307534.10
    Conserved Domains (1) summary
    TIGR00555
    Location:100453
    panK_eukar; pantothenate kinase, eukaryotic/staphyloccocal type
  3. NM_148978.3NP_683879.1  pantothenate kinase 1 isoform beta

    See identical proteins and their annotated locations for NP_683879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant alpha. The encoded isoform (beta) has a distinct N-terminus and is shorter than isoform alpha.
    Source sequence(s)
    AL157400, AY027662
    Consensus CDS
    CCDS7406.1
    UniProtKB/TrEMBL
    B3KXQ7
    Related
    ENSP00000345118.3, ENST00000342512.4
    Conserved Domains (1) summary
    pfam03630
    Location:14362
    Fumble

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    89579495..89645242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016334.2XP_016871823.1  pantothenate kinase 1 isoform X2

  2. XM_017016333.3XP_016871822.1  pantothenate kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8TE04
    Conserved Domains (1) summary
    pfam03630
    Location:41389
    Fumble; Fumble
  3. XM_047425354.1XP_047281310.1  pantothenate kinase 1 isoform X3

  4. XM_017016336.2XP_016871825.1  pantothenate kinase 1 isoform X4

    UniProtKB/TrEMBL
    B3KXQ7
    Conserved Domains (1) summary
    pfam03630
    Location:10358
    Fumble; Fumble

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    90463392..90529134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366094.1XP_054222069.1  pantothenate kinase 1 isoform X2

  2. XM_054366093.1XP_054222068.1  pantothenate kinase 1 isoform X1

  3. XM_054366095.1XP_054222070.1  pantothenate kinase 1 isoform X3

  4. XM_054366096.1XP_054222071.1  pantothenate kinase 1 isoform X4