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ZFYVE1 zinc finger FYVE-type containing 1 [ Homo sapiens (human) ]

Gene ID: 53349, updated on 17-Jun-2019

Summary

Official Symbol
ZFYVE1provided by HGNC
Official Full Name
zinc finger FYVE-type containing 1provided by HGNC
Primary source
HGNC:HGNC:13180
See related
Ensembl:ENSG00000165861 MIM:605471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172
Summary
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See ZFYVE1 in Genome Data Viewer
Location:
14q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (72969445..73027136, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73436152..73493920, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Cys (anticodon GCA) 8-1 Neighboring gene ribosomal protein S12 pseudogene 1 Neighboring gene uncharacterized LOC105370560 Neighboring gene RNA, 7SL, cytoplasmic 586, pseudogene Neighboring gene required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene Neighboring gene RNA binding motif protein 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1589

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
Mitochondria-associated ER Membrane IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of omegasome membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with membrane IDA
Inferred from Direct Assay
more info
PubMed 
omegasome IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger FYVE domain-containing protein 1
Names
double FYVE-containing protein 1
phosphoinositide-binding protein SR3
protein phosphatase 1, regulatory subunit 172
tandem FYVE fingers-1 protein
zinc finger protein, subfamily 2A, member 1
zinc finger, FYVE domain containing 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281734.2NP_001268663.1  zinc finger FYVE domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001268663.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL442663, BC014902, DA324499, DB059103, EL734498
    Consensus CDS
    CCDS61498.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000326921.5, ENST00000318876.9
    Conserved Domains (3) summary
    cd01851
    Location:174410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:697757
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:580641
    PHD_SF; PHD finger superfamily
  2. NM_001281735.1NP_001268664.1  zinc finger FYVE domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001268664.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AK098542, AL442663, AW070816, BU740588, BX339655, CK005173, HY248287
    Consensus CDS
    CCDS41969.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000377757.2, ENST00000394207.6
    Conserved Domains (2) summary
    cd15734
    Location:296356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:179240
    PHD_SF; PHD finger superfamily
  3. NM_021260.4NP_067083.1  zinc finger FYVE domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_067083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB046809, BC053520, HY248287
    Consensus CDS
    CCDS9811.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000450742.1, ENST00000556143.6
    Conserved Domains (3) summary
    cd01851
    Location:174410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594655
    FYVE_like_SF; FYVE domain like superfamily
  4. NM_178441.2NP_848535.1  zinc finger FYVE domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_848535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AF311602, AI073571, AW070816, BX339655, CK005173, HY248287
    Consensus CDS
    CCDS41969.1
    UniProtKB/Swiss-Prot
    Q9HBF4
    Related
    ENSP00000452232.1, ENST00000555072.1
    Conserved Domains (2) summary
    cd15734
    Location:296356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:179240
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    72969445..73027136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021373.1XP_016876862.1  zinc finger FYVE domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9HBF4
    Conserved Domains (2) summary
    cd15734
    Location:296356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl22851
    Location:179240
    PHD_SF; PHD finger superfamily

RNA

  1. XR_001750376.2 RNA Sequence

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