Format

Send to:

Choose Destination

TM6SF1 transmembrane 6 superfamily member 1 [ Homo sapiens (human) ]

Gene ID: 53346, updated on 7-Jun-2020

Summary

Official Symbol
TM6SF1provided by HGNC
Official Full Name
transmembrane 6 superfamily member 1provided by HGNC
Primary source
HGNC:HGNC:11860
See related
Ensembl:ENSG00000136404 MIM:606562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 3.4), thyroid (RPKM 3.0) and 24 other tissues See more
Orthologs

Genomic context

See TM6SF1 in Genome Data Viewer
Location:
15q25.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (83107587..83145403)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83776301..83806111)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene BTB domain containing 1 Neighboring gene fatty acid binding protein 5 pseudogene 8 Neighboring gene microRNA 4515 Neighboring gene HDGF like 3 Neighboring gene uncharacterized LOC105370932 Neighboring gene basonuclin 1 Neighboring gene uncharacterized LOC105370933

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transmembrane 6 superfamily member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144903.3NP_001138375.1  transmembrane 6 superfamily member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC024270, AK292100, BC063487, DQ021909
    Consensus CDS
    CCDS45338.1
    UniProtKB/Swiss-Prot
    Q9BZW5
    Related
    ENSP00000457477.1, ENST00000565774.5
    Conserved Domains (1) summary
    pfam10914
    Location:233322
    DUF2781; Protein of unknown function (DUF2781)
  2. NM_001330385.3NP_001317314.1  transmembrane 6 superfamily member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Consensus CDS
    CCDS81915.1
    UniProtKB/TrEMBL
    Q6P4D7
    Related
    ENSP00000368700.6, ENST00000379390.10
  3. NM_001353878.2NP_001340807.1  transmembrane 6 superfamily member 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Conserved Domains (1) summary
    pfam10914
    Location:217307
    DUF2781; Protein of unknown function (DUF2781)
  4. NM_001353879.2NP_001340808.1  transmembrane 6 superfamily member 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Conserved Domains (1) summary
    pfam10914
    Location:126262
    DUF2781; Protein of unknown function (DUF2781)
  5. NM_001353880.2NP_001340809.1  transmembrane 6 superfamily member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Conserved Domains (1) summary
    pfam10914
    Location:142231
    DUF2781; Protein of unknown function (DUF2781)
  6. NM_001353881.2NP_001340810.1  transmembrane 6 superfamily member 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Conserved Domains (1) summary
    pfam10914
    Location:69205
    DUF2781; Protein of unknown function (DUF2781)
  7. NM_001353882.2NP_001340811.1  transmembrane 6 superfamily member 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Conserved Domains (1) summary
    pfam10914
    Location:69205
    DUF2781; Protein of unknown function (DUF2781)
  8. NM_001353883.2NP_001340812.1  transmembrane 6 superfamily member 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Conserved Domains (1) summary
    pfam10914
    Location:18154
    DUF2781; Protein of unknown function (DUF2781)
  9. NM_001353884.2NP_001340813.1  transmembrane 6 superfamily member 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Conserved Domains (1) summary
    pfam10914
    Location:18154
    DUF2781; Protein of unknown function (DUF2781)
  10. NM_023003.5NP_075379.2  transmembrane 6 superfamily member 1 isoform 1

    See identical proteins and their annotated locations for NP_075379.2

    Status: VALIDATED

    Source sequence(s)
    AC024270, AK292100, BC063487
    Consensus CDS
    CCDS10323.1
    UniProtKB/Swiss-Prot
    Q9BZW5
    Related
    ENSP00000317000.9, ENST00000322019.14
    Conserved Domains (1) summary
    pfam10914
    Location:217353
    DUF2781; Protein of unknown function (DUF2781)

RNA

  1. NR_148560.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Related
    ENST00000379384.9
  2. NR_148561.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024270, BC063487
    Related
    ENST00000258909.13

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    83107587..83145403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022331.2XP_016877820.1  transmembrane 6 superfamily member 1 isoform X7

    UniProtKB/TrEMBL
    Q6P4D7
  2. XM_017022329.2XP_016877818.1  transmembrane 6 superfamily member 1 isoform X7

    UniProtKB/TrEMBL
    Q6P4D7
  3. XM_017022330.1XP_016877819.1  transmembrane 6 superfamily member 1 isoform X7

    UniProtKB/TrEMBL
    Q6P4D7
  4. XM_017022322.1XP_016877811.1  transmembrane 6 superfamily member 1 isoform X4

  5. XM_017022320.1XP_016877809.1  transmembrane 6 superfamily member 1 isoform X1

  6. XM_017022321.1XP_016877810.1  transmembrane 6 superfamily member 1 isoform X3

  7. XM_011521679.2XP_011519981.1  transmembrane 6 superfamily member 1 isoform X2

    Conserved Domains (1) summary
    pfam10914
    Location:217307
    DUF2781; Protein of unknown function (DUF2781)
  8. XM_017022325.1XP_016877814.1  transmembrane 6 superfamily member 1 isoform X5

  9. XM_024449953.1XP_024305721.1  transmembrane 6 superfamily member 1 isoform X6

    Conserved Domains (1) summary
    pfam10914
    Location:18108
    DUF2781; Protein of unknown function (DUF2781)

RNA

  1. XR_001751320.1 RNA Sequence

  2. XR_931848.2 RNA Sequence

  3. XR_001751319.2 RNA Sequence

  4. XR_001751318.1 RNA Sequence

Support Center