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BTK Bruton tyrosine kinase [ Bos taurus (domestic cattle) ]

Gene ID: 533459, updated on 5-Sep-2025
Official Symbol
BTKprovided by VGNC
Official Full Name
Bruton tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:26601
See related
BGD:BT12261; EnsemblRapid:ENSBTAG00070025269
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See BTK in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (50826842..50860745)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene galactosidase alpha Neighboring gene ribosomal protein L36a Neighboring gene microRNA mir-11999 Neighboring gene translocase of inner mitochondrial membrane 8A Neighboring gene TATA-box binding protein associated factor 7 like

Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Wang Q, et al. Elife, 2015 Feb 20. PMID 25699547, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. inositol hexakisphosphate (IP6), a soluble signaling molecule found in both animal and plant cells, also activates Btk.
    Title: Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC126902

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase BTK
Names
Bruton agammaglobulinemia tyrosine kinase
NP_001029761.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034589.2 → NP_001029761.1  tyrosine-protein kinase BTK

    See identical proteins and their annotated locations for NP_001029761.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102753
    UniProtKB/TrEMBL
    A0AAA9THY4, Q3ZC95
    Related
    ENSBTAP00070034173.1, ENSBTAT00070057326.1
    Conserved Domains (6) summary
    cd05113
    Location:397 → 652
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:274 → 379
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:217 → 271
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:6 → 166
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:4 → 133
    PH; PH domain
    pfam07714
    Location:402 → 651
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    50826842..50860745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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