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SPA17 sperm autoantigenic protein 17 [ Homo sapiens (human) ]

Gene ID: 53340, updated on 17-Jun-2019

Summary

Official Symbol
SPA17provided by HGNC
Official Full Name
sperm autoantigenic protein 17provided by HGNC
Primary source
HGNC:HGNC:11210
See related
Ensembl:ENSG00000064199 MIM:608621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT22; SP17; SP17-1
Summary
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
Expression
Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues See more
Orthologs

Genomic context

See SPA17 in Genome Data Viewer
Location:
11q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (124673844..124694794)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124543740..124564690)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta regulator 1 Neighboring gene RNA, 5S ribosomal pseudogene 352 Neighboring gene sialic acid acetylesterase Neighboring gene uncharacterized LOC107984405 Neighboring gene neurogranin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 
epithelial cilium movement NAS
Non-traceable Author Statement
more info
PubMed 
single fertilization TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 
sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sperm surface protein Sp17
Names
cancer/testis antigen 22
sperm protein 17

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017425.3NP_059121.1  sperm surface protein Sp17

    See identical proteins and their annotated locations for NP_059121.1

    Status: REVIEWED

    Source sequence(s)
    AF334735, DA511916
    Consensus CDS
    CCDS8450.1
    UniProtKB/Swiss-Prot
    Q15506
    UniProtKB/TrEMBL
    A0A172Q397
    Related
    ENSP00000227135.2, ENST00000227135.6
    Conserved Domains (2) summary
    smart00015
    Location:117135
    IQ; Calmodulin-binding motif
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    124673844..124694794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448583.1XP_024304351.1  sperm surface protein Sp17 isoform X1

    Conserved Domains (2) summary
    smart00015
    Location:117135
    IQ; Calmodulin-binding motif
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  2. XM_011542870.2XP_011541172.1  sperm surface protein Sp17 isoform X1

    See identical proteins and their annotated locations for XP_011541172.1

    UniProtKB/Swiss-Prot
    Q15506
    UniProtKB/TrEMBL
    A0A172Q397
    Related
    ENSP00000432305.1, ENST00000532692.1
    Conserved Domains (2) summary
    smart00015
    Location:117135
    IQ; Calmodulin-binding motif
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
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