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SPA17 sperm autoantigenic protein 17 [ Homo sapiens (human) ]

Gene ID: 53340, updated on 27-Nov-2024

Summary

Official Symbol
SPA17provided by HGNC
Official Full Name
sperm autoantigenic protein 17provided by HGNC
Primary source
HGNC:HGNC:11210
See related
Ensembl:ENSG00000064199 MIM:608621; AllianceGenome:HGNC:11210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT22; SP17; SP17-1
Summary
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
Expression
Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues See more
Orthologs
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Genomic context

See SPA17 in Genome Data Viewer
Location:
11q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124673904..124697518)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124702562..124726178)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124543800..124567414)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5688 Neighboring gene transforming growth factor beta regulator 1 Neighboring gene RNA, 5S ribosomal pseudogene 352 Neighboring gene sialic acid acetylesterase Neighboring gene ReSE screen-validated silencer GRCh37_chr11:124543663-124543821 Neighboring gene uncharacterized LOC124902780 Neighboring gene MPRA-validated peak1498 silencer Neighboring gene uncharacterized LOC107984405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124615273-124615806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124616341-124616874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4027 Neighboring gene neurogranin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sperm surface protein Sp17
Names
cancer/testis antigen 22
sperm protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017425.4NP_059121.1  sperm surface protein Sp17

    See identical proteins and their annotated locations for NP_059121.1

    Status: REVIEWED

    Source sequence(s)
    AF334735, AP000890
    Consensus CDS
    CCDS8450.1
    UniProtKB/Swiss-Prot
    B2R4F2, Q15506, Q9BXF7
    UniProtKB/TrEMBL
    A0A172Q397, Q05D07
    Related
    ENSP00000227135.2, ENST00000227135.7
    Conserved Domains (2) summary
    smart00015
    Location:117135
    IQ; Calmodulin-binding motif
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    124673904..124697518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448583.2XP_024304351.1  sperm surface protein Sp17 isoform X1

    UniProtKB/Swiss-Prot
    B2R4F2, Q15506, Q9BXF7
    UniProtKB/TrEMBL
    A0A172Q397, Q05D07
    Conserved Domains (2) summary
    smart00015
    Location:117135
    IQ; Calmodulin-binding motif
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  2. XM_011542870.3XP_011541172.1  sperm surface protein Sp17 isoform X1

    See identical proteins and their annotated locations for XP_011541172.1

    UniProtKB/Swiss-Prot
    B2R4F2, Q15506, Q9BXF7
    UniProtKB/TrEMBL
    A0A172Q397, Q05D07
    Related
    ENSP00000432305.1, ENST00000532692.1
    Conserved Domains (2) summary
    smart00015
    Location:117135
    IQ; Calmodulin-binding motif
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    124702562..124726178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369135.1XP_054225110.1  sperm surface protein Sp17 isoform X1

    UniProtKB/Swiss-Prot
    B2R4F2, Q15506, Q9BXF7
    UniProtKB/TrEMBL
    A0A172Q397
  2. XM_054369134.1XP_054225109.1  sperm surface protein Sp17 isoform X1

    UniProtKB/Swiss-Prot
    B2R4F2, Q15506, Q9BXF7
    UniProtKB/TrEMBL
    A0A172Q397