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PRKG2 protein kinase cGMP-dependent 2 [ Bos taurus (domestic cattle) ]

Gene ID: 533330, updated on 4-Oct-2024

Summary

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Official Symbol
PRKG2provided by VGNC
Official Full Name
protein kinase cGMP-dependent 2provided by VGNC
Primary source
VGNC:VGNC:33341
See related
BGD:BT19450; Ensembl:ENSBTAG00000002978
Gene type
protein coding
RefSeq status
INFERRED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PRKG2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (95867278..96003716, complement)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 299 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene bone morphogenetic protein 3 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC112447109 Neighboring gene RasGEF domain family member 1B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2. Koltes JE, et al. BMC Res Notes, 2015 Apr 30. PMID 25924610, Free PMC Article
  2. A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle. Koltes JE, et al. Proc Natl Acad Sci U S A, 2009 Nov 17. PMID 19887637, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study indicates that loss of PRKG2 function results in differential expression of P53 regulated genes as well as additional pathways consistent with increased proliferation and apoptosis in the growth plate due to achondroplastic dwarfism.
    Title: Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2.
  2. PRKG2 R678X as a causative mutation for dwarfism cattle was presented.
    Title: A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cGMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cGMP-dependent protein kinase 2
Names
cGMP-dependant type II protein kinase
protein kinase, cGMP-dependent, type II
NP_001137571.1
XP_024849054.1
XP_024849057.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144099.1 → NP_001137571.1  cGMP-dependent protein kinase 2

    See identical proteins and their annotated locations for NP_001137571.1

    Status: INFERRED

    Source sequence(s)
    AAFC03077638, AAFC03077640, AAFC03077642, AAFC03077643
    UniProtKB/TrEMBL
    D5HSX1
    Related
    ENSBTAP00000003877.5, ENSBTAT00000003877.5
    Conserved Domains (2) summary
    cd00038
    Location:286 → 401
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:459 → 718
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    95867278..96003716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024993286.2 → XP_024849054.1  cGMP-dependent protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    D5HSX1
    Conserved Domains (2) summary
    cd00038
    Location:286 → 401
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:459 → 718
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

  2. XM_024993289.2 → XP_024849057.1  cGMP-dependent protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cd05572
    Location:1 → 238
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
Nucleotide Protein Strain
Heading Accession and Version

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