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Pgrmc1 progesterone receptor membrane component 1 [ Mus musculus (house mouse) ]

Gene ID: 53328, updated on 9-May-2024

Summary

Official Symbol
Pgrmc1provided by MGI
Official Full Name
progesterone receptor membrane component 1provided by MGI
Primary source
MGI:MGI:1858305
See related
Ensembl:ENSMUSG00000006373 AllianceGenome:MGI:1858305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPR; PPMR; Vema; HPR6.6
Summary
Enables heme binding activity. Predicted to be involved in several processes, including heme biosynthetic process; learning or memory; and positive regulation of protein localization to plasma membrane. Located in mitochondrial outer membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study non-alcoholic fatty liver disease. Orthologous to human PGRMC1 (progesterone receptor membrane component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 269.7), adrenal adult (RPKM 243.6) and 27 other tissues See more
Orthologs
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Genomic context

See Pgrmc1 in Genome Data Viewer
Location:
X A3.3; X 21.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35861846..35869732)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36598193..36606079)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22364 Neighboring gene predicted gene 14569 Neighboring gene A kinase anchor protein 17B Neighboring gene STARR-seq mESC enhancer starr_46998 Neighboring gene ribosomal protein L7, pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipoprotein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
membrane-associated progesterone receptor component 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016783.4NP_058063.2  membrane-associated progesterone receptor component 1

    See identical proteins and their annotated locations for NP_058063.2

    Status: VALIDATED

    Source sequence(s)
    AK153272, BP770245, CK618071
    Consensus CDS
    CCDS30060.1
    UniProtKB/Swiss-Prot
    O55022, Q99JN0
    UniProtKB/TrEMBL
    Q3TH84, Q3TXU8
    Related
    ENSMUSP00000073061.7, ENSMUST00000073339.7
    Conserved Domains (1) summary
    pfam00173
    Location:72136
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    35861846..35869732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)