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Nptx2 neuronal pentraxin 2 [ Mus musculus (house mouse) ]

Gene ID: 53324, updated on 8-Nov-2022

Summary

Official Symbol
Nptx2provided by MGI
Official Full Name
neuronal pentraxin 2provided by MGI
Primary source
MGI:MGI:1858209
See related
Ensembl:ENSMUSG00000059991 AllianceGenome:MGI:1858209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
np2; Narp
Summary
Predicted to enable carbohydrate binding activity and metal ion binding activity. Acts upstream of or within associative learning. Predicted to be located in extracellular region. Predicted to be active in glutamatergic synapse. Is expressed in embryo; gut endoderm; and heart. Orthologous to human NPTX2 (neuronal pentraxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 14.8), frontal lobe adult (RPKM 13.5) and 17 other tissues See more
Orthologs
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Genomic context

See Nptx2 in Genome Data Viewer
Location:
5 G2; 5 84.58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144482697..144494288)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144545887..144557478)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33714 Neighboring gene predicted gene, 33765 Neighboring gene predicted gene, 54313 Neighboring gene predicted pseudogene 6272

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extrinsic component of postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuronal pentraxin-2
Names
NP-II
neuro activity regulated petaxin
neuronal pentraxin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016789.3NP_058069.1  neuronal pentraxin-2 precursor

    See identical proteins and their annotated locations for NP_058069.1

    Status: VALIDATED

    Source sequence(s)
    AC164119, AK134806, DV649643
    Consensus CDS
    CCDS19849.1
    UniProtKB/Swiss-Prot
    O70340
    UniProtKB/TrEMBL
    Q3UYB9
    Related
    ENSMUSP00000071687.7, ENSMUST00000071782.8
    Conserved Domains (2) summary
    smart00159
    Location:217422
    PTX; Pentraxin / C-reactive protein / pentaxin family
    cl03951
    Location:66185
    CDC37_N; Cdc37 N terminal kinase binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    144482697..144494288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)