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Folh1 folate hydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 53320, updated on 10-Oct-2020

Summary

Official Symbol
Folh1provided by MGI
Official Full Name
folate hydrolase 1provided by MGI
Primary source
MGI:MGI:1858193
See related
Ensembl:ENSMUSG00000001773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mo; GCP; GCP2; mopsm
Expression
Biased expression in kidney adult (RPKM 9.1), genital fat pad adult (RPKM 4.5) and 4 other tissues See more
Orthologs

Genomic context

See Folh1 in Genome Data Viewer
Location:
7; 7 D3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (86365733..86425171, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (86716525..86776053, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (93867486..93924374, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor 293 Neighboring gene olfactory receptor 292 Neighboring gene vomeronasal 2, receptor 77 Neighboring gene vomeronasal 2, receptor, pseudogene 87

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Clone Names

  • MGC141397

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
folic acid-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glutamate carboxypeptidase 2
Names
FGCP
GCPII
N-acetylated-alpha-linked acidic dipeptidase I
NAALADase I
folylpoly-gamma-glutamate carboxypeptidase
glutamate carboxypeptidase II
mGCP
membrane glutamate carboxypeptidase
prostate-specific membrane antigen homolog
pteroylpoly-gamma-glutamate carboxypeptidase
NP_001153178.1
NP_058050.3
XP_006508086.1
XP_011240163.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159706.1NP_001153178.1  glutamate carboxypeptidase 2 isoform 2

    See identical proteins and their annotated locations for NP_001153178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK002920, BB179784, BB872570, BC119604, BC119605
    Consensus CDS
    CCDS52300.1
    UniProtKB/Swiss-Prot
    O35409
    UniProtKB/TrEMBL
    Q0VDM6
    Related
    ENSMUSP00000102892.3, ENSMUST00000107271.9
    Conserved Domains (3) summary
    cd08022
    Location:275564
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:122365
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:601716
    TFR_dimer; Transferrin receptor-like dimerization domain
  2. NM_016770.3NP_058050.3  glutamate carboxypeptidase 2 isoform 1

    See identical proteins and their annotated locations for NP_058050.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK002920, BB179784, BB872570, BC119605
    Consensus CDS
    CCDS21436.1
    UniProtKB/Swiss-Prot
    O35409
    Related
    ENSMUSP00000001824.5, ENSMUST00000001824.6
    Conserved Domains (4) summary
    cd08022
    Location:356597
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:122348
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:634749
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:70116
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    86365733..86425171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508023.5XP_006508086.1  glutamate carboxypeptidase 2 isoform X1

  2. XM_011241861.4XP_011240163.1  glutamate carboxypeptidase 2 isoform X2

    Conserved Domains (2) summary
    cd02121
    Location:122348
    PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
    cl14876
    Location:356438
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RNA

  1. XR_004934143.1 RNA Sequence

  2. XR_003946512.2 RNA Sequence

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