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PLCB4 phospholipase C beta 4 [ Homo sapiens (human) ]

Gene ID: 5332, updated on 6-Jan-2020

Summary

Official Symbol
PLCB4provided by HGNC
Official Full Name
phospholipase C beta 4provided by HGNC
Primary source
HGNC:HGNC:9059
See related
Ensembl:ENSG00000101333 MIM:600810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARCND2; PI-PLC
Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Expression
Broad expression in thyroid (RPKM 7.9), salivary gland (RPKM 5.4) and 19 other tissues See more
Orthologs

Genomic context

See PLCB4 in Genome Data Viewer
Location:
20p12.3-p12.2
Exon count:
46
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (9068710..9480816)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9049357..9461463)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 1 Neighboring gene RNA, U105B small nucleolar Neighboring gene uncharacterized LOC105372522 Neighboring gene Sharpr-MPRA regulatory region 7247 Neighboring gene uncharacterized LOC105372523 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene p21 (RAC1) activated kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Auriculocondylar syndrome 2
MedGen: C3553404 OMIM: 614669 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
inositol trisphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Names
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
PLC-beta-4
dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))
inositoltrisphosphohydrolase
monophosphatidylinositol phosphodiesterase
phosphoinositidase C
phosphoinositide phospholipase C-beta-4
triphosphoinositide phosphodiesterase
NP_000924.3
NP_001166117.1
NP_877949.2
XP_005260781.1
XP_005260785.1
XP_006723631.1
XP_006723632.1
XP_011527556.1
XP_016883369.1
XP_016883370.1
XP_016883371.1
XP_016883372.1
XP_016883373.1
XP_016883375.1
XP_024307666.1
XP_024307667.1
XP_024307668.1
XP_024307669.1
XP_024307670.1
XP_024307671.1
XP_024307672.1
XP_024307673.1
XP_024307674.1
XP_024307675.1
XP_024307676.1
XP_024307677.1
XP_024307678.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032790.2 RefSeqGene

    Range
    5001..416763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000933.4NP_000924.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    See identical proteins and their annotated locations for NP_000924.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the central coding region and includes an alternate exon in the 3' coding region that results in a frameshift, compared to variant 3. The complete exon combination of the 5' UTR for this variant has not been determined. The resulting isoform (a) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS13104.1
    UniProtKB/Swiss-Prot
    Q15147
    Related
    ENSP00000367762.2, ENST00000378501.2
    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8471194
    Neuromodulin_N; Gap junction protein N-terminal region
  2. NM_001172646.1NP_001166117.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform c.
    Source sequence(s)
    AK307837, AL117633, BC143868, DB270238, DN913865
    Consensus CDS
    CCDS54447.1
    UniProtKB/Swiss-Prot
    Q15147
    Related
    ENSP00000367734.3, ENST00000378473.7
    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8511182
    Neuromodulin_N; Gap junction protein N-terminal region
  3. NM_001377134.1NP_001364063.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
  4. NM_001377135.1NP_001364064.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
  5. NM_001377136.1NP_001364065.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
  6. NM_001377142.1NP_001364071.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
  7. NM_001377143.1NP_001364072.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
  8. NM_182797.3NP_877949.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    See identical proteins and their annotated locations for NP_877949.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 3. The complete exon combination of the 5' UTR for this variant has not been determined. The resulting isoform (b) lacks an internal segment, compared to isoform c.
    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS13105.1
    UniProtKB/Swiss-Prot
    Q15147
    Related
    ENSP00000278655.4, ENST00000278655.8
    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8391170
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    9068710..9480816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027880.1XP_016883369.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    UniProtKB/Swiss-Prot
    Q15147
    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8471194
    Neuromodulin_N; Gap junction protein N-terminal region
  2. XM_005260724.2XP_005260781.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_005260781.1

    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8591206
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_017027883.1XP_016883372.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6

  4. XM_024451901.1XP_024307669.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8471194
    Neuromodulin_N; Gap junction protein N-terminal region
  5. XM_024451898.1XP_024307666.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8591206
    Neuromodulin_N; Gap junction protein N-terminal region
  6. XM_024451904.1XP_024307672.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

    Related
    ENSP00000390616.2, ENST00000414679.6
    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8511182
    Neuromodulin_N; Gap junction protein N-terminal region
  7. XM_024451909.1XP_024307677.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7

    Conserved Domains (6) summary
    cd00275
    Location:601717
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:199567
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    pfam06631
    Location:813854
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:35187
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl17171
    Location:130
    PH-like; Pleckstrin homology-like domain
    cl26511
    Location:7461093
    Neuromodulin_N; Gap junction protein N-terminal region
  8. XM_024451905.1XP_024307673.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8391170
    Neuromodulin_N; Gap junction protein N-terminal region
  9. XM_024451907.1XP_024307675.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8391170
    Neuromodulin_N; Gap junction protein N-terminal region
  10. XM_024451908.1XP_024307676.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7

    Conserved Domains (6) summary
    cd00275
    Location:601717
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:199567
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    pfam06631
    Location:813854
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:35187
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl17171
    Location:130
    PH-like; Pleckstrin homology-like domain
    cl26511
    Location:7461093
    Neuromodulin_N; Gap junction protein N-terminal region
  11. XM_024451910.1XP_024307678.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7

    Conserved Domains (6) summary
    cd00275
    Location:601717
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:199567
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    pfam06631
    Location:813854
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:35187
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl17171
    Location:130
    PH-like; Pleckstrin homology-like domain
    cl26511
    Location:7461093
    Neuromodulin_N; Gap junction protein N-terminal region
  12. XM_017027881.1XP_016883370.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    UniProtKB/Swiss-Prot
    Q15147
    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8391170
    Neuromodulin_N; Gap junction protein N-terminal region
  13. XM_006723568.3XP_006723631.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8591206
    Neuromodulin_N; Gap junction protein N-terminal region
  14. XM_024451902.1XP_024307670.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8471194
    Neuromodulin_N; Gap junction protein N-terminal region
  15. XM_024451903.1XP_024307671.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8471194
    Neuromodulin_N; Gap junction protein N-terminal region
  16. XM_024451906.1XP_024307674.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    Conserved Domains (6) summary
    cd00275
    Location:702818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914955
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8391170
    Neuromodulin_N; Gap junction protein N-terminal region
  17. XM_024451899.1XP_024307667.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8591206
    Neuromodulin_N; Gap junction protein N-terminal region
  18. XM_006723569.2XP_006723632.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006723632.1

    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8591206
    Neuromodulin_N; Gap junction protein N-terminal region
  19. XM_024451900.1XP_024307668.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    Conserved Domains (6) summary
    cd00275
    Location:714830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:8591206
    Neuromodulin_N; Gap junction protein N-terminal region
  20. XM_017027882.1XP_016883371.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

  21. XM_017027884.1XP_016883373.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7

    Conserved Domains (6) summary
    cd00275
    Location:601717
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:199567
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    pfam06631
    Location:813854
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:35187
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl17171
    Location:130
    PH-like; Pleckstrin homology-like domain
    cl26511
    Location:7461093
    Neuromodulin_N; Gap junction protein N-terminal region
  22. XM_011529254.2XP_011527556.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8

    Conserved Domains (6) summary
    cd00275
    Location:554670
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:152520
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:58659
    PLN02228; Phosphoinositide phospholipase C
    pfam06631
    Location:766806
    DUF1154; Protein of unknown function (DUF1154)
    pfam09279
    Location:61152
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam09728
    Location:7811018
    Taxilin; Myosin-like coiled-coil protein
  23. XM_017027886.1XP_016883375.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X10

  24. XM_005260728.2XP_005260785.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X9

    Conserved Domains (5) summary
    cd00275
    Location:446562
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:44412
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    pfam06631
    Location:658698
    DUF1154; Protein of unknown function (DUF1154)
    pfam09279
    Location:144
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam09728
    Location:673910
    Taxilin; Myosin-like coiled-coil protein
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