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Pdlim3 PDZ and LIM domain 3 [ Mus musculus (house mouse) ]

Gene ID: 53318, updated on 1-Nov-2022

Summary

Official Symbol
Pdlim3provided by MGI
Official Full Name
PDZ and LIM domain 3provided by MGI
Primary source
MGI:MGI:1859274
See related
Ensembl:ENSMUSG00000031636 AllianceGenome:MGI:1859274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALP; Actn2lp
Summary
Enables cytoskeletal protein binding activity. A structural constituent of muscle. Acts upstream of or within actin filament organization and heart development. Located in actin cytoskeleton. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb bud; and retina. Used to study arrhythmogenic right ventricular cardiomyopathy. Orthologous to human PDLIM3 (PDZ and LIM domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 302.3), colon adult (RPKM 44.0) and 8 other tissues See more
Orthologs
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Genomic context

See Pdlim3 in Genome Data Viewer
Location:
8; 8 B1.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46338524..46372672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45885487..45919635)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene sorbin and SH3 domain containing 2 Neighboring gene sorbin and SH3 domain containing 2, opposite strand Neighboring gene predicted gene, 25309 Neighboring gene RIKEN cDNA 1700029J07 gene Neighboring gene coiled-coil domain containing 110 Neighboring gene UFM1-specific peptidase 2 Neighboring gene ankyrin repeat domain 37

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of muscle IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc TAS
Traceable Author Statement
more info
PubMed 
located_in actin cytoskeleton IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PDZ and LIM domain protein 3
Names
actinin alpha 2 associated LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374652.2NP_001361581.1  PDZ and LIM domain protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC113469, AC114558
    Consensus CDS
    CCDS90393.1
    UniProtKB/TrEMBL
    A0A1B0GSX6
    Related
    ENSMUSP00000148113.2, ENSMUST00000210422.2
    Conserved Domains (3) summary
    cd09450
    Location:294346
    LIM_ALP; This family represents the LIM domain of ALP, actinin-associated LIM protein
    cd00992
    Location:280
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:184268
    DUF4749; Domain of unknown function (DUF4749)
  2. NM_016798.5NP_058078.1  PDZ and LIM domain protein 3 isoform 2

    See identical proteins and their annotated locations for NP_058078.1

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC114558
    Consensus CDS
    CCDS22281.1
    UniProtKB/Swiss-Prot
    O70209
    Related
    ENSMUSP00000034053.6, ENSMUST00000034053.7
    Conserved Domains (3) summary
    cd09450
    Location:246298
    LIM_ALP; This family represents the LIM domain of ALP, actinin-associated LIM protein
    cd00992
    Location:280
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:137220
    DUF4749; Domain of unknown function (DUF4749)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    46338524..46372672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)