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Batf basic leucine zipper transcription factor, ATF-like [ Mus musculus (house mouse) ]

Gene ID: 53314, updated on 5-Mar-2024

Summary

Official Symbol
Batfprovided by MGI
Official Full Name
basic leucine zipper transcription factor, ATF-likeprovided by MGI
Primary source
MGI:MGI:1859147
See related
Ensembl:ENSMUSG00000034266 AllianceGenome:MGI:1859147
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B-ATF; SFA-2
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to protozoan; immune system development; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in bladder and testis. Orthologous to human BATF (basic leucine zipper ATF-like transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 6.8), thymus adult (RPKM 3.8) and 21 other tissues See more
Orthologs
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Genomic context

See Batf in Genome Data Viewer
Location:
12 D2; 12 39.78 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85733494..85755861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85686720..85709087)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32783 Neighboring gene Jun dimerization protein 2 Neighboring gene predicted gene, 33312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:87002012-87002121 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:87027519-87027764 Neighboring gene STARR-positive B cell enhancer ABC_E10767 Neighboring gene nuclear encoded rRNA 5S 64 Neighboring gene STARR-seq mESC enhancer starr_32787 Neighboring gene feline leukemia virus subgroup C cellular receptor 2 Neighboring gene predicted gene, 40478

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 17 cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 2 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphoid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
basic leucine zipper transcriptional factor ATF-like
Names
B-cell-activating transcription factor
activating transcription factor B
basic leucine zipper transcription factor-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016767.2NP_058047.1  basic leucine zipper transcriptional factor ATF-like

    See identical proteins and their annotated locations for NP_058047.1

    Status: PROVISIONAL

    Source sequence(s)
    AC115037, AC117240
    Consensus CDS
    CCDS26061.1
    UniProtKB/Swiss-Prot
    A2RT86, O35284
    Related
    ENSMUSP00000040706.6, ENSMUST00000040536.6
    Conserved Domains (1) summary
    cd14701
    Location:2683
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85733494..85755861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)