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MSH2 mutS homolog 2 [ Bos taurus (cattle) ]

Gene ID: 533115, updated on 17-Sep-2018

Summary

Official Symbol
MSH2provided by VGNC
Official Full Name
mutS homolog 2provided by VGNC
Primary source
VGNC:VGNC:31693
See related
Ensembl:ENSBTAG00000002742
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

See MSH2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 11 NC_037338.1 (29804982..29886264)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 11 AC_000168.1 (29648305..29730537)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene epithelial cell adhesion molecule Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium two pore domain channel subfamily K member 12 Neighboring gene WAS/WASL-interacting protein family member 3-like

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC129013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MutLalpha complex binding IEA
Inferred from Electronic Annotation
more info
 
centromeric DNA binding IEA
Inferred from Electronic Annotation
more info
 
dinucleotide repeat insertion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidized purine DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
single guanine insertion binding IEA
Inferred from Electronic Annotation
more info
 
single thymine insertion binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of helicase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of isotype switching to IgA isotypes IEA
Inferred from Electronic Annotation
more info
 
positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MutSalpha complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
DNA mismatch repair protein Msh2
Names
mutS homolog 2, colon cancer, nonpolyposis type 1
mutS protein homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034584.1NP_001029756.1  DNA mismatch repair protein Msh2

    See identical proteins and their annotated locations for NP_001029756.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105268
    UniProtKB/Swiss-Prot
    Q3MHE4
    Related
    ENSBTAP00000003556.4, ENSBTAT00000003556.4
    Conserved Domains (6) summary
    cd03285
    Location:633852
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:23853
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:18132
    MutS_I; MutS domain I
    pfam05188
    Location:158284
    MutS_II; MutS domain II
    pfam05190
    Location:473569
    MutS_IV; MutS family domain IV
    pfam05192
    Location:305423
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    29804982..29886264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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