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IARS2 isoleucyl-tRNA synthetase 2, mitochondrial [ Bos taurus (domestic cattle) ]

Gene ID: 533057, updated on 5-Sep-2025
Official Symbol
IARS2provided by VGNC
Official Full Name
isoleucyl-tRNA synthetase 2, mitochondrialprovided by VGNC
Primary source
VGNC:VGNC:30019
See related
BGD:BT29807; EnsemblRapid:ENSBTAG00070009692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See IARS2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (23586935..23631282)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene glutamyl-prolyl-tRNA synthetase 1 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene microRNA mir-194-1 Neighboring gene microRNA mir-194b Neighboring gene microRNA mir-215 Neighboring gene RAB3 GTPase activating non-catalytic protein subunit 2 Neighboring gene microRNA mir-664b Neighboring gene transfer RNA glycine (anticodon CCC)

Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. IARS mutation causes prenatal death in Japanese Black cattle. Hirano T, et al. Anim Sci J, 2016 Sep. PMID 27229878
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Its mutation causes prenatal death in Japanese Black cattle
    Title: IARS mutation causes prenatal death in Japanese Black cattle.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aminoacyl-tRNA deacylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables isoleucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in isoleucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
isoleucine--tRNA ligase, mitochondrial
Names
isoleucine-tRNA synthetase 2, mitochondrial
NP_001193724.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206795.1 → NP_001193724.1  isoleucine--tRNA ligase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    BC102830, DT812568, DV887098, DV894430
    UniProtKB/TrEMBL
    G3MWG4
    Related
    ENSBTAP00070012757.1, ENSBTAT00070021752.1
    Conserved Domains (5) summary
    cd07960
    Location:711 → 890
    Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
    PRK05743
    Location:60 → 1011
    ileS; isoleucyl-tRNA synthetase; Reviewed
    pfam06827
    Location:985 → 1006
    zf-FPG_IleRS; Zinc finger found in FPG and IleRS
    pfam13603
    Location:356 → 410
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    cl00015
    Location:472 → 708
    nt_trans; nucleotidyl transferase superfamily

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    23586935..23631282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials