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CDC42 cell division cycle 42 [ Bos taurus (domestic cattle) ]

Gene ID: 532712, updated on 5-Sep-2025
Official Symbol
CDC42provided by VGNC
Official Full Name
cell division cycle 42provided by VGNC
Primary source
VGNC:VGNC:97251
See related
EnsemblRapid:ENSBTAG00070010271
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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See CDC42 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (130733638..130754601, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 4 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC101905607 Neighboring gene SCAN domain containing 1-like Neighboring gene chymotrypsin-like elastase family, member 3B

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Prioritising guidance cues: directional migration induced by substratum contours and electrical gradients is controlled by a rho/cdc42 switch. Rajnicek AM, et al. Dev Biol, 2007 Dec 1. PMID 17976566
  2. The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42. Alonso-Hearn M, et al. Infect Immun, 2008 Jan. PMID 17938223, Free PMC Article
  3. Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress. Tzima E, et al. J Biol Chem, 2003 Aug 15. PMID 12754216
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study revealed a novel signaling pathway activated during M. avium subsp. paratuberculosis entry that links the product of MAP3464 gene to activation of Cdc42 in the host cell.
    Title: The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42.
  2. These data are consistent with the idea that migrating corneal epithelial cells use a cdc42/rho "switch" to sort vectoral cues, with cdc42 controlling electrotaxis and rho controlling contact guidance.
    Title: Prioritising guidance cues: directional migration induced by substratum contours and electrical gradients is controlled by a rho/cdc42 switch.
  3. shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex.
    Title: Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC128612

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in modification of synaptic structure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cell division control protein 42 homolog
Names
cell division cycle 42 (GTP binding protein, 25kDa)
NP_001039797.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046332.1 → NP_001039797.1  cell division control protein 42 homolog

    See identical proteins and their annotated locations for NP_001039797.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105461
    UniProtKB/Swiss-Prot
    Q2KJ93
    UniProtKB/TrEMBL
    B6VAP7
    Related
    ENSBTAP00070013521.1, ENSBTAT00070022991.1
    Conserved Domains (1) summary
    cd01874
    Location:3 → 177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    130733638..130754601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KJ93.1 GenPept UniProtKB/Swiss-Prot:Q2KJ93

Gene LinkOut

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