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ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [ Bos taurus (domestic cattle) ]

Gene ID: 532663, updated on 10-Feb-2026
Official Symbol
ENPP2provided by VGNC
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 2provided by VGNC
Primary source
VGNC:VGNC:28505
See related
EnsemblRapid:ENSBTAG00070018254
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ENPP2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (80982686..81118870, complement)

Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100335514 Neighboring gene zinc finger AN1-type containing 1 Neighboring gene solute carrier family 10 member 5 Neighboring gene inositol monophosphatase 1 Neighboring gene microRNA mir-2285n-6 Neighboring gene uncharacterized LOC104974144 Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene DNA replication and sister chromatid cohesion 1

Genomic Sequence:
NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Which bovine endometrial cells are the source of and target for lysophosphatidic acid? Boruszewska D, et al. Reprod Biol, 2013 Mar. PMID 23522079
  2. Cyclic phosphatidic acid is produced by autotaxin in blood. Tsuda S, et al. J Biol Chem, 2006 Sep 8. PMID 16837466
  3. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. Umezu-Goto M, et al. J Cell Biol, 2002 Jul 22. PMID 12119361, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression is greater in epithelial cells than in stromal cells of the endometrium
    Title: Which bovine endometrial cells are the source of and target for lysophosphatidic acid?
  2. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.
    Title: Cyclic phosphatidic acid is produced by autotaxin in blood.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC142749

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alkylglycerophosphoethanolamine phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylcholine lysophospholipase A1 activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphodiesterase I activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in estrous cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylcholine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
autotaxin
Names
E-NPP 2
ectonucleotide pyrophosphatase/phosphodiesterase family member 2
extracellular lysophospholipase D
lysoPLD
NP_001073762.1
XP_010810523.1
XP_015330019.1
XP_015330020.1
XP_015330021.1
XP_015330022.1
XP_024857378.1
XP_024857380.2
XP_024857381.1
XP_024857382.2
XP_024857383.1
XP_024857384.2
XP_024857385.1
XP_024857386.1
XP_024857388.2
XP_059749269.1
XP_059749270.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080293.1 → NP_001073762.1  autotaxin precursor

    See identical proteins and their annotated locations for NP_001073762.1

    Status: PROVISIONAL

    Source sequence(s)
    BC126631
    UniProtKB/Swiss-Prot
    A1A4K5
    UniProtKB/TrEMBL
    A0A3Q1MWK8
    Related
    ENSBTAP00070024639.1, ENSBTAT00070041290.1
    Conserved Domains (4) summary
    smart00201
    Location:55 → 98
    SO; Somatomedin B -like domains
    smart00477
    Location:640 → 870
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:166 → 478
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:164 → 518
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    80982686..81118870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015474534.3 → XP_015330020.1  autotaxin isoform X3

    UniProtKB/TrEMBL
    A0AAF6ZCL7
    Conserved Domains (4) summary
    smart00201
    Location:122 → 165
    SO; Somatomedin B -like domains
    smart00477
    Location:734 → 964
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:233 → 597
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:231 → 637
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  2. XM_015474533.3 → XP_015330019.1  autotaxin isoform X1

    UniProtKB/TrEMBL
    A0AAF6ZCL7
    Conserved Domains (4) summary
    smart00201
    Location:122 → 165
    SO; Somatomedin B -like domains
    smart00477
    Location:759 → 989
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:233 → 597
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:231 → 637
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  3. XM_015474536.3 → XP_015330022.1  autotaxin isoform X9

    UniProtKB/TrEMBL
    A0A3Q1LYS8, A0AAF6ZCL7
    Related
    ENSBTAP00070024657.1, ENSBTAT00070041329.1
    Conserved Domains (4) summary
    smart00201
    Location:122 → 165
    SO; Somatomedin B -like domains
    smart00477
    Location:682 → 912
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:233 → 545
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:231 → 585
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  4. XM_015474535.3 → XP_015330021.1  autotaxin isoform X5

    UniProtKB/TrEMBL
    A0A3Q1MWK8
    Conserved Domains (4) summary
    smart00201
    Location:122 → 165
    SO; Somatomedin B -like domains
    smart00477
    Location:707 → 937
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:233 → 545
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:231 → 585
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  5. XM_059893287.1 → XP_059749270.1  autotaxin isoform X16

    UniProtKB/TrEMBL
    A0AAF6ZCL7

  6. XM_025001617.2 → XP_024857385.1  autotaxin isoform X14

    UniProtKB/TrEMBL
    A0A3Q1MWK8
    Conserved Domains (3) summary
    smart00201
    Location:45 → 88
    SO; Somatomedin B -like domains
    smart00477
    Location:630 → 860
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:156 → 468
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

  7. XM_059893286.1 → XP_059749269.1  autotaxin isoform X12

    UniProtKB/TrEMBL
    A0AAF6ZCL7

  8. XM_025001613.2 → XP_024857381.1  autotaxin isoform X8

    UniProtKB/TrEMBL
    A0AAF6ZCL7
    Conserved Domains (3) summary
    smart00201
    Location:45 → 88
    SO; Somatomedin B -like domains
    smart00477
    Location:682 → 912
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:156 → 520
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

  9. XM_025001620.2 → XP_024857388.2  autotaxin isoform X13

    UniProtKB/TrEMBL
    A0AAA9TBJ2
    Related
    ENSBTAP00070024651.1, ENSBTAT00070041318.1

  10. XM_025001616.2 → XP_024857384.2  autotaxin isoform X10

    UniProtKB/TrEMBL
    A0AAA9RX78
    Related
    ENSBTAP00070024645.1, ENSBTAT00070041302.1

  11. XM_025001614.2 → XP_024857382.2  autotaxin isoform X6

    UniProtKB/TrEMBL
    A0AAA9TBJ2

  12. XM_025001612.2 → XP_024857380.2  autotaxin isoform X4

    UniProtKB/TrEMBL
    A0AAA9RX78

  13. XM_010812221.4 → XP_010810523.1  autotaxin isoform X7

    UniProtKB/TrEMBL
    A0AAF6ZCL7
    Related
    ENSBTAP00070024628.1, ENSBTAT00070041271.1
    Conserved Domains (4) summary
    smart00201
    Location:55 → 98
    SO; Somatomedin B -like domains
    smart00477
    Location:692 → 922
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:166 → 530
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:164 → 570
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  14. XM_025001618.2 → XP_024857386.1  autotaxin isoform X15

    UniProtKB/TrEMBL
    A0AAF6ZCL7
    Conserved Domains (3) summary
    smart00201
    Location:55 → 98
    SO; Somatomedin B -like domains
    smart00477
    Location:615 → 845
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:166 → 478
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

  15. XM_025001615.1 → XP_024857383.1  autotaxin isoform X11

    UniProtKB/TrEMBL
    A0AAA9T0V7, A0AAF6ZCL7
    Related
    ENSBTAP00070024616.1, ENSBTAT00070041243.1
    Conserved Domains (3) summary
    smart00201
    Location:58 → 101
    SO; Somatomedin B -like domains
    smart00477
    Location:618 → 848
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:169 → 481
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

  16. XM_025001610.2 → XP_024857378.1  autotaxin isoform X2

    UniProtKB/TrEMBL
    A0AAF6ZCL7
    Conserved Domains (3) summary
    smart00201
    Location:19 → 62
    SO; Somatomedin B -like domains
    smart00477
    Location:656 → 886
    NUC; DNA/RNA non-specific endonuclease
    pfam01663
    Location:130 → 494
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1A4K5.1 GenPept UniProtKB/Swiss-Prot:A1A4K5

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