PLAGL2 PLAG1 like zinc finger 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLAGL2provided by HGNC
Official Full Name: PLAG1 like zinc finger 2provided by HGNC
Primary source: HGNC:HGNC:9047
See related: Ensembl:ENSG00000126003 MIM:604866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZNF900
Summary: Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]
Expression: Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 20q11.21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109.20191205	current	GRCh38.p13 (GCF_000001405.39)	20	NC_000020.11 (32192504..32207743, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (30780307..30795546, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our team identified for the first time a bidirectional promoter pair oncogene, PLAGL2-POFUT1, in colorectal cancer (CRC).
Title: PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.
DJ-1 can promote CRC metastasis by activating PLAGL2-Wnt-BMP4 axis.
Title: DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis.
PLAGL2 expression is strongly associated with an IESC signature in colorectal cancer and may be responsible for contributing to the aberrant activation of an immature phenotype.
Title: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells.
PLAGL2 is highly expressed in the bladder urothelial carcinoma tissue and metastatic lymph node relative to the normal bladder tissue.
Title: Expression of PLAGL2 in bladder urothelial carcinoma and its relationship to lymph node metastasis and survival.
Study results indicated that PLAGL2 was overexpressed in colorectal cancer (CRC) as a protooncogene and that it could active the Wnt/betacatenin pathway as a transcription factor by binding with the promoter region of Wnt6.
Title: Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer.
overexpression of miR-449a inhibited the expression of PLAGL2 significantly and the knockdown of PLAGL2 expression inhibited the breast cancer cell proliferation and metastasis
Title: MiR-449a suppresses cell migration and invasion by targeting PLAGL2 in breast cancer.
increased expression correlates to prostate cancer progression following radical prostatectomy and may serve as novel poor prognostic marker
Title: Overexpression of Pleomorphic Adenoma Gene-Like 2 Is a Novel Poor Prognostic Marker of Prostate Cancer.
Our findings indicated that PLAGL2 might be a very upstream key molecule regulating Epithelial-mesenchymal transition involved in Wnt/bcatenin signaling pathway in Colorectal adenocarcinoma
Title: Pleomorphic adenoma gene like-2 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human colorectal adenocarcinoma.
Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer
Title: The role of pleomorphic adenoma gene-like 2 in gastrointestinal cancer development, progression, and prognosis.
PLAGL2 expression induces lamellipodia formation and disruption of stress fiber formation.
Title: PLAGL2 regulates actin cytoskeletal architecture and cell migration.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PLAGL2_1372 (e-PCR)
- UniSTS:280913

RH25411 (e-PCR)
- UniSTS:62333

G59261 (e-PCR)
- UniSTS:136576

Homology

Homologs of the PLAGL2 gene: The PLAGL2 gene is conserved in chimpanzee, dog, cow, mouse, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 294 organisms have orthologs with human gene PLAGL2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	NAS Non-traceable Author Statement more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
chylomicron assembly	IEA Inferred from Electronic Annotation more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
post-embryonic development	IEA Inferred from Electronic Annotation more info
transcription, DNA-templated	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein PLAGL2

Names: C2H2-type zinc finger protein; pleiomorphic adenoma gene-like 2; pleiomorphic adenoma-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002657.3 → NP_002648.1 zinc finger protein PLAGL2

See identical proteins and their annotated locations for NP_002648.1

Status: REVIEWED

Source sequence(s)

AL121897, BC023655

Consensus CDS

CCDS13197.1

UniProtKB/Swiss-Prot

Q9UPG8

Related

ENSP00000246229.4, ENST00000246229.5

Conserved Domains (2) summary

sd00017
Location:70 → 92

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:85 → 109

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p13 Primary Assembly

Range

32192504..32207743 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528864.2 → XP_011527166.1 zinc finger protein PLAGL2 isoform X1

See identical proteins and their annotated locations for XP_011527166.1

UniProtKB/Swiss-Prot

Q9UPG8

Conserved Domains (2) summary

sd00017
Location:70 → 92

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:85 → 109

zf-H2C2_2; Zinc-finger double domain
XM_005260436.3 → XP_005260493.1 zinc finger protein PLAGL2 isoform X1

See identical proteins and their annotated locations for XP_005260493.1

UniProtKB/Swiss-Prot

Q9UPG8

Conserved Domains (2) summary

sd00017
Location:70 → 92

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:85 → 109

zf-H2C2_2; Zinc-finger double domain