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PLAGL2 PLAG1 like zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 5326, updated on 19-Sep-2021

Summary

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Official Symbol
PLAGL2provided by HGNC
Official Full Name
PLAG1 like zinc finger 2provided by HGNC
Primary source
HGNC:HGNC:9047
See related
Ensembl:ENSG00000126003 MIM:604866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF900
Summary
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues See more
Orthologs
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Genomic context

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See PLAGL2 in Genome Data Viewer
Location:
20q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (32192504..32207743, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30780307..30795546, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal L24 domain containing 1 pseudogene 6 Neighboring gene testis specific protein Y-linked 26, pseudogene Neighboring gene protein O-fucosyltransferase 1 Neighboring gene microRNA 1825 Neighboring gene kinesin family member 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1. Wu L, et al. Theranostics, 2021. PMID 33391500, Free PMC Article
  2. Expression of PLAGL2 in bladder urothelial carcinoma and its relationship to lymph node metastasis and survival. Qu G, et al. Sci Rep, 2018 Apr 16. PMID 29662235, Free PMC Article
  3. Pleomorphic adenoma gene like-2 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human colorectal adenocarcinoma. Wang YP, et al. Oncol Rep, 2017 Apr. PMID 28259923, Free PMC Article
  4. Overexpression of Pleomorphic Adenoma Gene-Like 2 Is a Novel Poor Prognostic Marker of Prostate Cancer. Guo J, et al. PLoS One, 2016. PMID 27537362, Free PMC Article
  5. The role of pleomorphic adenoma gene-like 2 in gastrointestinal cancer development, progression, and prognosis. Liu B, et al. Int J Clin Exp Pathol, 2014. PMID 25031728, Free PMC Article

See all (42) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer.
    Title: MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer.
  2. Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis.
    Title: Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis.
  3. PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1.
    Title: PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1.
  4. The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression.
    Title: The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression.
  5. PLAGL2 promotes epithelial-mesenchymal transition and mediates colorectal cancer metastasis via beta-catenin-dependent regulation of ZEB1.
    Title: PLAGL2 promotes epithelial-mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1.
  6. Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2.
    Title: Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2.
  7. PLAGL2 and POFUT1 were common and upregulated in tumor samples in colorectal cancer (CRC). Survival analysis of PLAGL2 and POFUT1 expression revealed differences between proximal and distal CRC. PLAGL2 and POFUT1, which have the highest correlation with tumor location, may serve as biomarkers and therapeutic targets for the precise diagnosis and treatment of CRC in the future.
    Title: Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer.
  8. Our team identified for the first time a bidirectional promoter pair oncogene, PLAGL2-POFUT1, in colorectal cancer (CRC).
    Title: PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.
  9. DJ-1 can promote CRC metastasis by activating PLAGL2-Wnt-BMP4 axis.
    Title: DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis.
  10. PLAGL2 expression is strongly associated with an IESC signature in colorectal cancer and may be responsible for contributing to the aberrant activation of an immature phenotype.
    Title: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chylomicron assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein PLAGL2
Names
C2H2-type zinc finger protein
pleiomorphic adenoma gene-like 2
pleiomorphic adenoma-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002657.3 → NP_002648.1  zinc finger protein PLAGL2

    See identical proteins and their annotated locations for NP_002648.1

    Status: REVIEWED

    Source sequence(s)
    AL121897, BC023655
    Consensus CDS
    CCDS13197.1
    UniProtKB/Swiss-Prot
    Q9UPG8
    Related
    ENSP00000246229.4, ENST00000246229.5
    Conserved Domains (2) summary
    sd00017
    Location:70 → 92
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85 → 109
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    32192504..32207743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528864.2 → XP_011527166.1  zinc finger protein PLAGL2 isoform X1

    See identical proteins and their annotated locations for XP_011527166.1

    UniProtKB/Swiss-Prot
    Q9UPG8
    Conserved Domains (2) summary
    sd00017
    Location:70 → 92
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85 → 109
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005260436.3 → XP_005260493.1  zinc finger protein PLAGL2 isoform X1

    See identical proteins and their annotated locations for XP_005260493.1

    UniProtKB/Swiss-Prot
    Q9UPG8
    Conserved Domains (2) summary
    sd00017
    Location:70 → 92
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85 → 109
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPG8.1 GenPept UniProtKB/Swiss-Prot:Q9UPG8

Gene LinkOut

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