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PLAGL2 PLAG1 like zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 5326, updated on 11-Jun-2025
Official Symbol
PLAGL2provided by HGNC
Official Full Name
PLAG1 like zinc finger 2provided by HGNC
Primary source
HGNC:HGNC:9047
See related
Ensembl:ENSG00000126003 MIM:604866; AllianceGenome:HGNC:9047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF900
Summary
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues See more
Orthologs
NEW
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See PLAGL2 in Genome Data Viewer
Location:
20q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32192504..32207743, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33916427..33931666, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30780307..30795546, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal L24 domain containing 1 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30762883-30763484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30763485-30764084 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30768259-30768439 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30769860-30770360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30776057-30776872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12777 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30779125-30779322 Neighboring gene testis specific protein Y-linked 26, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30784106-30784868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17712 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30795517-30796430 Neighboring gene protein O-fucosyltransferase 1 Neighboring gene uncharacterized LOC124904884 Neighboring gene microRNA 1825

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ23283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein PLAGL2
Names
C2H2-type zinc finger protein
pleiomorphic adenoma gene-like 2
pleiomorphic adenoma-like protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002657.3NP_002648.1  zinc finger protein PLAGL2

    See identical proteins and their annotated locations for NP_002648.1

    Status: REVIEWED

    Source sequence(s)
    AL121897, BC023655
    Consensus CDS
    CCDS13197.1
    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
    Related
    ENSP00000246229.4, ENST00000246229.5
    Conserved Domains (2) summary
    sd00017
    Location:7092
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85109
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32192504..32207743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440200.1XP_047296156.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
  2. XM_011528864.3XP_011527166.1  zinc finger protein PLAGL2 isoform X1

    See identical proteins and their annotated locations for XP_011527166.1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
    Conserved Domains (2) summary
    sd00017
    Location:7092
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85109
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005260436.4XP_005260493.1  zinc finger protein PLAGL2 isoform X1

    See identical proteins and their annotated locations for XP_005260493.1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
    Conserved Domains (2) summary
    sd00017
    Location:7092
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85109
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    33916427..33931666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323512.1XP_054179487.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
  2. XM_054323511.1XP_054179486.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
  3. XM_054323510.1XP_054179485.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8