U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PLAGL2 PLAG1 like zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 5326, updated on 11-Jun-2025
Official Symbol
PLAGL2provided by HGNC
Official Full Name
PLAG1 like zinc finger 2provided by HGNC
Primary source
HGNC:HGNC:9047
See related
Ensembl:ENSG00000126003 MIM:604866; AllianceGenome:HGNC:9047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF900
Summary
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See PLAGL2 in Genome Data Viewer
Location:
20q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32192504..32207743, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33916427..33931666, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30780307..30795546, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal L24 domain containing 1 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30762883-30763484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30763485-30764084 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30768259-30768439 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30769860-30770360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30776057-30776872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12777 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30779125-30779322 Neighboring gene testis specific protein Y-linked 26, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30784106-30784868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17712 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30795517-30796430 Neighboring gene protein O-fucosyltransferase 1 Neighboring gene uncharacterized LOC124904884 Neighboring gene microRNA 1825

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Overexpression of Pleomorphic Adenoma Gene-Like 2 Is a Novel Poor Prognostic Marker of Prostate Cancer. Guo J, et al. PLoS One, 2016. PMID 27537362, Free PMC Article
  2. PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia. Guo Y, et al. Biochem Biophys Res Commun, 2007 Aug 31. PMID 17618602, Free PMC Article
  3. PLAGL2 regulates actin cytoskeletal architecture and cell migration. Sekiya R, et al. Carcinogenesis, 2014 Sep. PMID 24675530
  4. PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/β-catenin Pathway. Jin W, et al. Ann Clin Lab Sci, 2022 May. PMID 35777795
  5. PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway. Li Y, et al. Genes Genomics, 2023 Jan. PMID 36399309

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression.
    Title: POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression.
  2. PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
    Title: PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
  3. Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer.
    Title: Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer.
  4. PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer.
    Title: PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer.
  5. PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway.
    Title: PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway.
  6. Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
    Title: Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
  7. LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/beta-catenin/cyclin D1 signaling via PLAGL2.
    Title: LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/β-catenin/cyclin D1 signaling via PLAGL2.
  8. PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/beta-catenin Pathway.
    Title: PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/β-catenin Pathway.
  9. Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma.
    Title: Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma.
  10. MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer.
    Title: MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chylomicron assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein PLAGL2
Names
C2H2-type zinc finger protein
pleiomorphic adenoma gene-like 2
pleiomorphic adenoma-like protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002657.3 → NP_002648.1  zinc finger protein PLAGL2

    See identical proteins and their annotated locations for NP_002648.1

    Status: REVIEWED

    Source sequence(s)
    AL121897, BC023655
    Consensus CDS
    CCDS13197.1
    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
    Related
    ENSP00000246229.4, ENST00000246229.5
    Conserved Domains (2) summary
    sd00017
    Location:70 → 92
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85 → 109
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32192504..32207743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440200.1 → XP_047296156.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8

  2. XM_011528864.3 → XP_011527166.1  zinc finger protein PLAGL2 isoform X1

    See identical proteins and their annotated locations for XP_011527166.1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
    Conserved Domains (2) summary
    sd00017
    Location:70 → 92
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85 → 109
    zf-H2C2_2; Zinc-finger double domain

  3. XM_005260436.4 → XP_005260493.1  zinc finger protein PLAGL2 isoform X1

    See identical proteins and their annotated locations for XP_005260493.1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
    Conserved Domains (2) summary
    sd00017
    Location:70 → 92
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:85 → 109
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    33916427..33931666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323512.1 → XP_054179487.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8

  2. XM_054323511.1 → XP_054179486.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8

  3. XM_054323510.1 → XP_054179485.1  zinc finger protein PLAGL2 isoform X1

    UniProtKB/Swiss-Prot
    A8K8T5, E1P5M3, Q92584, Q9UPG8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPG8.1 GenPept UniProtKB/Swiss-Prot:Q9UPG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools