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PLA2G1B phospholipase A2 group IB [ Homo sapiens (human) ]

Gene ID: 5319, updated on 11-Sep-2019

Summary

Official Symbol
PLA2G1Bprovided by HGNC
Official Full Name
phospholipase A2 group IBprovided by HGNC
Primary source
HGNC:HGNC:9030
See related
Ensembl:ENSG00000170890 MIM:172410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLA2; PLA2A; PPLA2
Summary
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Expression
Restricted expression toward pancreas (RPKM 9662.9) See more
Orthologs

Genomic context

See PLA2G1B in Genome Data Viewer
Location:
12q24.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120322115..120327779, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120759914..120765592, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene RNA, U4 small nuclear 1 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene musashi RNA binding protein 1 Neighboring gene ribosomal protein S27 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119834, MGC119835

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bile acid binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
activation of phospholipase A2 activity TAS
Traceable Author Statement
more info
PubMed 
antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid secretion TAS
Traceable Author Statement
more info
PubMed 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response in mucosa IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-8 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
leukotriene biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neutrophil mediated immunity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein secretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase A2
Names
phosphatidylcholine 2-acylhydrolase 1B
phospholipase A2, group IB (pancreas)
NP_000919.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000928.3NP_000919.1  phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_000919.1

    Status: VALIDATED

    Source sequence(s)
    AA844927, M21054
    Consensus CDS
    CCDS9195.1
    UniProtKB/Swiss-Prot
    P04054
    Related
    ENSP00000312286.4, ENST00000308366.9
    Conserved Domains (1) summary
    smart00085
    Location:24146
    PA2c; Phospholipase A2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120322115..120327779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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