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CYM chymosin [ Bos taurus (domestic cattle) ]

Gene ID: 529879, updated on 5-Aug-2026
Official Symbol
CYMprovided by VGNC
Official Full Name
chymosinprovided by VGNC
Primary source
VGNC:VGNC:108923
See related
BGD:BT11742; Ensembl:ENSBTAG00070013892
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CPC; Chy
Try the new Gene page
Try the new Transcripts and proteins table
See CYM in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (32944105..32954997, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344988 Neighboring gene potassium voltage-gated channel subfamily A member 10 Neighboring gene prokineticin 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Camel and bovine chymosin: the relationship between their structures and cheese-making properties. Langholm Jensen J, et al. Acta Crystallogr D Biol Crystallogr, 2013 May. PMID 23633601, Free PMC Article
  2. Short communication: Identification and characterization of multiple splicing forms of bovine prochymosin mRNA. Zinovieva N, et al. J Dairy Sci, 2002 Dec. PMID 12512621
  3. Nucleotide sequence of calf prorennin cDNA cloned in Escherichia coli. Nishimori K, et al. J Biochem, 1982 Mar. PMID 6804449
  4. Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin. Harris TJ, et al. Nucleic Acids Res, 1982 Apr 10. PMID 6283469, Free PMC Article
  5. Molecular cloning and characterization of double-stranded cDNA coding for bovine chymosin. Moir D, et al. Gene, 1982 Jul-Aug. PMID 6183168

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of bovine chymosin shows relationship with cheese making properties
    Title: Camel and bovine chymosin: the relationship between their structures and cheese-making properties.
  2. molecular dynamics simulation of bovine chymosin complexed with the P9-P70 residues of bovine kappa-casein
    Title: Bovine chymosin: a computational study of recognition and binding of bovine kappa-casein.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
chymosin
Names
preprorennin
prochymosin
rennin
NP_851337.1
XP_005204185.1
XP_005204186.1
XP_005204187.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180994.2 → NP_851337.1  chymosin preproprotein

    See identical proteins and their annotated locations for NP_851337.1

    Status: PROVISIONAL

    Source sequence(s)
    J00003
    UniProtKB/TrEMBL
    A0A3Q1MMC7
    Related
    ENSBTAP00070018602.1, ENSBTAT00070031456.1
    Conserved Domains (3) summary
    cd05478
    Location:64 → 379
    pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
    pfam00026
    Location:73 → 380
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:19 → 47
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    32944105..32954997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005204130.5 → XP_005204187.1  chymosin isoform X3

    UniProtKB/TrEMBL
    Q8SPG9
    Conserved Domains (3) summary
    pfam00026
    Location:73 → 309
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:19 → 47
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:64 → 308
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  2. XM_005204129.5 → XP_005204186.1  chymosin isoform X2

    UniProtKB/TrEMBL
    Q8SPH0
    Conserved Domains (3) summary
    pfam00026
    Location:73 → 342
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:19 → 47
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:64 → 341
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  3. XM_005204128.5 → XP_005204185.1  chymosin isoform X1

    UniProtKB/TrEMBL
    Q8SPH1
    Related
    ENSBTAP00070018584.1, ENSBTAT00070031397.1
    Conserved Domains (3) summary
    pfam00026
    Location:73 → 347
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:19 → 47
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:64 → 346
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00794.3 GenPept UniProtKB/Swiss-Prot:P00794

Gene LinkOut

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Molecular Biology Databases
Research Materials